Ischemic preconditioning small animal centrifuge
A small animal and centrifuge technology, applied in animal husbandry, etc., can solve the problems of cerebral ischemia, unpredictability, limited application, damage, and influence on data accuracy.
Active Publication Date: 2014-10-15
金建文 +5
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However, the current classic ischemic preconditioning is mostly invasive and damaging. For example, the ischemic preconditioning induced by the above drugs may cause interactions with other drugs in the follow-up experiment, thereby affecting the accuracy of the data obtained in the research. sex
[0004] In addition, the unpredictability of cerebral ischemia caused by invasive ischemic preconditioning also limits its clinical application
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[0032] The following disclosure provides many different embodiments or examples for implementing different structures of the present invention. To simplify the disclosure of the present invention, components and arrangements of specific examples are described below. Furthermore, the present invention may repeat reference numerals and / or letters in different instances. This repetition is for the purpose of simplicity and clarity and does not in itself indicate a relationship between the various embodiments and / or arrangements discussed. It should be noted that components illustrated in the figures are not necessarily drawn to scale. Descriptions of well-known components and processing techniques and processes are omitted herein to avoid unnecessarily limiting the present invention.
[0033] refer to Figure 1 ~ Figure 3 , you can clearly see the connection status of each part of the small animal centrifuge provided by the present invention. The small animal centrifuge is pe...
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The invention discloses a preparation method of an ischemic preconditioning model. The preparation method comprises the following steps of: placing and fixing a small animal for preparing the model in a mouse cage, enabling the body of the small animal to be vertical to a spindle of a small animal centrifuge and enabling the head of the small animal to be towards the axis; starting a motor and enabling the motor to rotate for 5 minutes according to a preset speed; stopping the motor for 5 minutes; repeating the steps for three times at intervals of 24 hours and obtaining the ischemic preconditioning model after 72 hours. Correspondingly, the invention also provides the small animal centrifuge for the preparation method. By adopting the small animal centrifuge provided by the invention, the ischemic preconditioning model for research can be simply and effectively obtained on the premise of not damaging the small animal.
Description
technical field [0001] The invention relates to medical experiment equipment for ischemic preconditioning, in particular to a small animal centrifuge for ischemic preconditioning. Background technique [0002] Ischemic Preconditioning (IPC) means that transient ischemia can protect organs in subsequent prolonged ischemia, so that ischemic damage can be controlled. Cerebal Ischemic Preconditioning (CIP) refers to the use of mechanical stimulation of brain tissue, such as one or more transient cerebral ischemia-reperfusion, resulting in the endogenous protection mechanism of brain tissue, so that it will be stable for a long time in the future. Temporal ischemic injury produces remarkable tolerance. This phenomenon is also called cerebral ischemic tolerance (Ischemic Tolerance, IT). [0003] Since it was reported that transient non-lethal ischemic preconditioning can significantly reduce subsequent cerebral ischemic injury, various ischemic preconditioning has been widely us...
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IPC IPC(8): A01K67/027
Inventor 刘俊乐黄睿赵峰裴树俊张浩金建文
Owner 金建文