Method for preparing compound sodium chloride injection prepared solution

A compound sodium chloride and injection technology, which is applied in the field of medicine, can solve the problems of not being suitable for industrial production, and achieve the effects of reducing impact, saving feeding time, and supporting reliable data

Inactive Publication Date: 2014-12-10
KUNMING NANJIANG PHARMA
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Problems solved by technology

[0007] At the same time, the detection of potassium chloride content in the preparation liquid needs 5-8 hours to be detected using the existing pharmacopoeia detection method, which is not suitable for industrialized production

Method used

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  • Method for preparing compound sodium chloride injection prepared solution
  • Method for preparing compound sodium chloride injection prepared solution

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Embodiment 1

[0029] Implementation 1: Preparation of 500ml Compound Sodium Chloride Injection

[0030] 1. According to the formula, we weigh 76.50kg of sodium chloride; 2.97kg of calcium chloride; 2.70kg of potassium chloride; and 4.50kg of concentrated medicinal charcoal.

[0031] 2. Open the water injection valve of the concentrated preparation tank, add about 1.5 million ml of water for injection above 70°C into the tank, put 76.5 kg of sodium chloride raw material into the tank one by one, stir for 5-10 minutes to dissolve and mix.

[0032] 3. Add 4.50kg of wet medicinal charcoal (activated carbon for needles) into the concentrated solution with a stainless steel spoon, and keep stirring to make the medicinal charcoal (activated carbon for needles) evenly dispersed in the concentrated solution.

[0033] 4. After the temperature of the concentrated solution is cooled to 60±5°C, decarburize and filter the concentrated sodium chloride solution through a 10um titanium rod, and send it into...

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Abstract

The invention relates to the field of medicines, in particular to a method for preparing a compound sodium chloride injection prepared solution. The method is characterized in that the concentrated preparation of sodium chloride is carried out in a concentrated solution preparing cylinder, and then, a concentrated sodium chloride solution is fed into a diluted solution preparing cylinder for diluting; first content detection is carried out after cooled injection water is added into the diluted solution preparing cylinder until the volume is the preparation total volume, and the content of the sodium chloride is measured; then, calcium chloride and potassium chloride are added, secondary content detection is carried out after mixing, and the content of the calcium chloride and the content of the potassium chloride are measured; the content of total chlorine is finally measured. As the contents of the ingredients sodium chloride, the calcium chloride and the potassium chloride in the prepared solution can be directly detected, the contents of all the ingredients are not required to be inferred through the measurement of the chlorine ion content, and the content evenness of all the ingredients of the prepared solution is accordingly ensured.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for preparing a compound sodium chloride injection preparation. Background technique [0002] Compound Sodium Chloride is a drug for supplementing and regulating body fluid water and electrolyte balance. It contains water for injection used to replenish body fluids, and sodium, calcium, and potassium ions are important electrolytes in body fluids, which play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. It is used for the treatment of dehydration caused by various reasons, including hypotonic, isotonic and hypertonic dehydration. [0003] However, if the content of sodium, calcium, and potassium ions is not well controlled, it will cause great harm to the human body. If the content is not enough, the medicinal effect will not be achieved, and even cause hemolysis. Potassium and chloride neutralize sodium to maintain sodi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/08A61P3/12A61P7/08G01N21/79
Inventor 肖宇刘懿鑫李德彪赵理忠范衡儒樊继孔高国辉余勇军李洪国刘思川万阳浴葛均友程志鹏
Owner KUNMING NANJIANG PHARMA
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