Rapid detection method of benzodiazepine and operation vessel combination thereof

Abstract

The invention provides a rapid detection method of benzodiazepine and an operation vessel combination thereof. The rapid detection method comprises the following steps of performing trituration on materials to be detected, adding an acid solution for extraction and obtaining an upper layer of extracting solution; adding a chromogenic agent into the extracting solution to perform a chromogenic reaction, determining whether a compound of benzodiazepines is added into the materials to be detected or not according to a chromogenic result and determining that the compound of benzodiazepines is contained in the materials to be detected if orange-red precipitates are generated in the extracting solution; determining that the compound of benzodiazepines is not contained in the materials to be detected if the orange-red precipitates are not generated in the extracting solution. According to the rapid detection method of the benzodiazepine and the operation vessel combination thereof, samples are dissolved through the dissolved liquid, the chromogenic effect of the samples is achieved through the chromogenic agent, the chromogenic result can be observed through naked eyes, the corresponding operation vessel combination is simple in operation and convenient to carry, expensive instrument equipment are not required, the detection process is rapid, the accuracy is high, and the corresponding operation vessel combination is suitable for screening of the large quantities of samples.

Description

[0001] technical field [0002] The invention relates to a rapid detection method of benzodiazepines, in particular to a rapid detection method of benzodiazepines in health care products, medicines and foods, especially health products for improving sleep, and a combination of operating utensils thereof . [0003] Background technique [0004] With the increasingly fierce competition and increasing pressure in modern society, many people suffer from anxiety and depression, which induce sleep disorders and insomnia. Patients need to rely on drugs to relieve these symptoms. Commonly used drugs include diazepam (stable), estazolam, etc. These belong to the second category of psychotropic drugs, and their use is strictly restricted. Therefore, for patients who need to take drugs for a long time, they have Hypnotic health products and Chinese patent medicines may become their first choice. [0005] Benzodiazepines (BZ) are currently commonly used sedative and hypnotic drugs in...

AI Technical Summary

Problems solved by technology

[0007] At present, the detection of illegal addition of benzodiazepines mainly adopts high-performance liquid chromatography-mass spectrometry / mass spectrometry technology. This technology requires expensive detection instruments, and the detection conditions are relatively complicated. There may also be operator training. , instrument maintenance and other issues, so it is very unfavorable to detect benzodiazepines in daily food, health care products and medicines

[0008] In addition, according to records, there are also high-performance liquid chromatography, gas chromatography, thin-layer chromatography, and thin-layer scanning methods for the determination of benzodiazepines, but these methods require complex pretreatment of samples At the same time, various consumables such as chromatographic columns and thin-layer plates are required, and the detection takes a long time, which is also not suitable for on-site supervision.