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Traditional Chinese medicine perfusate for treating dairy cow mastitis and preparation method thereof

A technology for dairy cow mastitis and perfusion fluid, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc.

Active Publication Date: 2018-05-25
HEBEI GREENLAND ANIMAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the dosage form prepared by it is a liniment, and through transdermal administration, the time of exerting drug effect is longer

Method used

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  • Traditional Chinese medicine perfusate for treating dairy cow mastitis and preparation method thereof
  • Traditional Chinese medicine perfusate for treating dairy cow mastitis and preparation method thereof
  • Traditional Chinese medicine perfusate for treating dairy cow mastitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment １

[0044] Example 1 A traditional Chinese medicine perfusate for the treatment of dairy cow mastitis and its preparation method

[0045] A traditional Chinese medicine perfusate for treating cow mastitis, which comprises the following traditional Chinese medicine ingredients in parts by weight:

[0046] Dandelion 60g, honeysuckle leaf 60g, forsythia 60g,

[0047] Scutellaria baicalensis 40g, Zihua Diding 30g, Radix Radix 40g,

[0048] Andrographis paniculata leaves 60g, Houttuynia cordata 50g.

[0049] Among them, dandelion is the monarch drug, honeysuckle, forsythia, scutellaria baicalensis, zihuadiding and Radix Radix are minister drugs, Andrographis paniculata and Houttuynia cordata are adjuvant drugs, all drugs are used together to play the effect of clearing away heat and detoxification, reducing swelling and dispelling carbuncle;

[0050] Dandelion has the functions of clearing heat and detoxification, reducing swelling and dissipating stagnation, and diuresis;

[0051] ...

Embodiment 2-6

[0078] Example 2-6 Chinese medicine perfusate for treating cow mastitis and preparation method thereof

[0079] Examples 2-6 are the traditional Chinese medicine perfusate for the treatment of dairy cow mastitis and its preparation method. The preparation process is similar to that of the examples. The only difference is that the dosage of traditional Chinese medicine and the technical parameters involved in the preparation method are different. For details, please refer to the following surface:

[0080]

[0081] Wherein, the volumes or weight multiples involved in the table are based on the parts by weight of the traditional Chinese medicine used in each sub-step.

Embodiment 7

[0082] Example 7 Condition experiment of ethanol step-by-step impurity removal in preparation step (1)

[0083] In the extraction steps of dandelion, honeysuckle, viola, andrographis paniculata leaves and houttuynia cordata, ethanol is used to carry out step-by-step impurity removal methods to purify them. In the prior art, the step-by-step method for purifying impurities is also used, but For different extraction substances, after combining them, on the basis of retaining the active ingredients of the raw materials, the impurities are removed as much as possible. Therefore, it is first purified with 70% ethanol, and then purified with 80% ethanol to make effective The ingredients are retained to the greatest extent, and the screening process is as follows:

[0084] First, screen the purification reagents and time selected for the first purification, the process is as follows:

[0085]

[0086] It can be seen from the above table that when ethanol is added to 65%, no matte...

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Abstract

The invention discloses traditional Chinese medicine perfusate for treating cow mastitis and a preparation method thereof. The traditional Chinese medicine perfusate is prepared from eight raw materials: dandelion, honeysuckle, fructus forsythia, scutellaria baicalensis, Chinese violet, radix isatidis, common andrographis herb leaves and cordate houttuynia, and belongs to a pure traditional Chinese medicine preparation; the pure traditional Chinese medicine preparation is safe in administration, and efficient in treatment; cordate houttuynia and radix isatidis in the preparation process are subjected to water extraction; impurity removal is carried out by adopting a ZTC1+1 clarifying agent; compared with impurity removal by using ethanol, the operation is simple; the production cost is low; each 1ml of prepared perfusate is equivalent to 1g of crude drugs, and has the characteristics of being low in toxicity, and free of residues; an animal body does not easily generate drug resistance; and the preparation method is suitable for preparation of the perfusate for treating cow mastitis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine perfusate and a preparation method thereof, in particular to a traditional Chinese medicine perfusate for treating cow mastitis and a preparation method thereof. Background technique [0002] Cow mastitis refers to the inflammation of the udder caused by various etiologies. Its main features are the physical and chemical properties and bacteriological changes of the milk, and the pathological changes of the mammary gland tissue. Clinical mastitis is easy to diagnose, but because most cases (recessive mastitis) are difficult to find abnormalities by hand palpation of the mammary glands, and it is also difficult to observe pathological changes by visual inspection of breast milk, so some people now define mastitis as infection of mammary glands A disorder in which the white blood cell count in breast milk is markedly increased, m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/86A61K9/00A61K47/30A61P15/14
CPCA61K9/0041A61K9/08A61K36/19A61K36/195A61K36/288A61K36/315A61K36/355A61K36/539A61K36/634A61K36/78A61K36/86A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 杨广平马金波吴兰金世清裴志勤赵素娟刘志峰崔士军
Owner HEBEI GREENLAND ANIMAL PHARMA CO LTD
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