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Use of 9ª‰-acetyl costunolide lactone as antitumour agent

A technology of acetyl and gingerolide, applied in the field of biomedicine, can solve the problems of the immune system being difficult to fight against bacteria and viruses, side effects, lack of cancer cell specificity, etc.

Inactive Publication Date: 2005-07-06
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while chemotherapy and radiotherapy kill cancer cells, they also kill normal cells of the host, causing serious side effects and destroying the immune function of the body, making it difficult for the immune system to fight against invading bacteria and viruses
The current anticancer drugs lack specificity and selectivity to cancer cells, and cannot effectively fight against the malignant transformation of tumor cells and the metastasis and spread of cancer after surgery.

Method used

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  • Use of 9ª‰-acetyl costunolide lactone as antitumour agent
  • Use of 9ª‰-acetyl costunolide lactone as antitumour agent
  • Use of 9ª‰-acetyl costunolide lactone as antitumour agent

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Embodiment

[0094] Use of the compound 9β-acetyl ashenolide as an anticancer agent.

[0095] 1. The compound 9β-acetyl ashenolide was separated and purified according to the following method:

[0096] 1) Dry and pulverize the whole plant of Chrysanthemum chrysanthemum, take 10 kg of pulverized samples, soak them in 95% ethanol for 30 days, extract the extract, and obtain the extract CP 0 ≈800 grams;

[0097] 2) Take 800 grams of this extract, mix it with diatomaceous earth in a ratio of 1:1, stir and mix evenly with 95% ethanol, dry it on a water bath, weigh it, W 样 =710 grams, with a 1L Soxhlet extractor, extract successively with sherwood oil, chloroform: ethyl acetate=3:1, ethyl acetate, acetone, methanol respectively, get crude component CP 1 (120g), CP 2 (100g), CP 3 (100g), CP 4 (130g), CP 5 (150 grams).

[0098] 3) Use L 1210 CP 1 ~CP 5 Cytotoxicity activity screening was carried out. As a result, the anticancer activity was in the order of CP 2 >CP 3 >CP 1 >CP 4 >CP 5...

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Abstract

The invention relates to the use of 9 beta-acetyl costunolide lactone as antitumour agent, which posscesses selectivity to five tumor cells of L1210, CCRF-CEM, KB, MCF-7 and LS174T, the IC50 of the 9beta-acetoxystunolide to the five tumor cells are 0.89, 0.65, 0.25, 1.28 and 0.63 ug / ml, the anticancer activity and pharmaceutical concentration are related to the time of the acting cancer cells, the cell toxicity activity to the L1210 cancer cell belongs to the cytotoxic type instead of Cytostatic type, the mechanism of cancer cell sterilizing is related to inhibition of microtubulin, the result is tumor cell necrosis instead of cell apoptosis. The agent can serve as a good anticancer agent.

Description

technical field [0001] The present invention relates to biomedicine, specifically compound 9β-acetyl ashenolide (9β-acetoxystunolide, also known as: 9β-acetyl ashenolide, self-coded as CP-C) as an anticancer agent application. Background technique [0002] Cancer is the second largest killer threatening human life, claiming about 7 million lives every year, and it is an international problem that needs to be solved urgently. Comprehensive treatment of surgery, chemotherapy, and radiotherapy is still the main means of treating cancer so far. However, while chemotherapy and radiotherapy kill cancer cells, they also kill normal cells of the host, causing serious side effects and destroying the immune function of the body, making it difficult for the immune system to fight against invading bacteria and viruses. Current anticancer drugs lack specificity and selectivity to cancer cells, and cannot effectively fight against malignant transformation of tumor cells and cancer metas...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P35/00
Inventor 李祖强
Owner YUNNAN UNIV
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