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Method of extracting terpene lactone from folium ginkgo leaves and product

A technology of terpene lactone and ginkgo biloba, which is applied in the field of products with high bilobalide content, can solve the problems of difficult recycling, high cost, cumbersome and time-consuming process, etc., and achieve the effect of simple process, less organic solvent and low product cost

Inactive Publication Date: 2007-02-28
湖北犇星新材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The general process is: after the ginkgo leaves are leached, the leaching solution passes through an alumina column, and then after extraction, passes through a silica gel column and an activated carbon column, and the solution is crystallized to obtain its product, but this process is cumbersome and time-consuming, and the used Alumina, silica gel and activated carbon are not easy to recycle, the cost is high, and the loss of lactone is serious, and the yield is only about 0.4%.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the ginkgo leaf (its water content is less than 10% by weight) that 100kg pulverizes is in reflux extraction tank with 50 volume % ethanol 700L, is heated to 80 ℃ of temperature, reflux extraction 2 hours, filter after extracting, add 50 volumes again The % ethanol aqueous solution was extracted twice, 400 L each time, extracted at a temperature of 80° C. for 2 hours, and the filtered filtrates were combined to obtain an extract. Concentrate the extract with an external circulation evaporator at a pressure of ≤-0.065Mpa until an alcohol-free concentrate is obtained, then add deionized water to 600L, cool to room temperature, leave for 6 hours, and filter. The filtrate is adsorbed through a 100kg HPD-100 macroporous resin column at a speed of 2L / min. The resin is produced by Hebei Cangzhou Baoen Chemical Factory Co., Ltd. After entering the feed liquid, let it stand for 10min, and first use 200L of deionized water at a flow rate of 2L Rinse / min, then elute ...

Embodiment 2

[0030] Example 2: In the reflux extraction tank, 100 kg of ginkgo leaves crushed into flakes were added with 650 L of 45 volume % ethanol, heated to 85 ° C, reflux extraction for 2 hours, filtered, and then 45 volume % ethanol was added for extraction twice, and the additions were in order 450L, 350L, extract at 85°C for 2 hours, filter, and combine the extracts. Use an external circulation evaporator to concentrate the extract to 300L at a pressure of ≤-0.065Mpa, add deionized water to 600L, cool to room temperature, leave it for 6 hours, and filter. The filtrate passes through the 100kg HPD-100 macroporous resin column at a speed of 3L / min. After entering the feed liquid, let it stand for 10min, add 300L of deionized water to pass through the column (flow rate 2L / min), and then use 400L of 15 volume % ethanol to pass through the column, and the outlet The effluent was discarded, followed by 400 L of 60 volume % ethanol to pass through the column, and the outlet liquid was co...

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PUM

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Abstract

A process for extracting terperiod ginkalide from ginkgo leaf and a product which is prepared by extracting in alcohol and resin concentrating and has high content of ginkalide are disclosed. Its advantages are low cost and less environmental pollution. Said product can be used for treating senile dementia and cardiovascular and cerebrovascular diseases.

Description

[technical field] [0001] The present invention relates to a method for extracting ginkgo terpene lactones from ginkgo leaves, in particular, the present invention relates to a method for extracting with alcohol and enriching resin, and a product with high bilobalide content obtained by this method and its application. [Background technique] [0002] Ginkgolides are diterpene lactones and sesquiterpene lactones with special structures found in Ginkgo biloba leaves. At present, Ginkgolide A, Ginkgolide B, Ginkgolide C, Ginkgolide M, Ginkgolide J and Bilobalide have been isolated from Ginkgo biloba leaves. This is the most promising specific and effective platelet activating factor (PAF) receptor antagonist recognized by the medical field today, and has high specificity. The latest pharmacological research results prove that ginkgolides have protective effects on ischemic injury and central nervous system. [0003] Ginkgolides have been isolated from Ginkgo biloba leaves for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30A61P25/28A61P9/10
Inventor 戴百雄宫庭钱军张金陵
Owner 湖北犇星新材料股份有限公司
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