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Application of insulin-like growth factor binding protein 5 in promotion of periodontal tissue regeneration

A periodontal tissue regeneration, stem cell technology, applied in the field of stem cells, can solve the problems of periodontal tissue regeneration and unclear mechanism

Active Publication Date: 2015-01-28
BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the effect and mechanism of IGFBP5 on osteogenic / odontogenic differentiation of mesenchymal stem cells and mediated periodontal tissue regeneration are unclear

Method used

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  • Application of insulin-like growth factor binding protein 5 in promotion of periodontal tissue regeneration
  • Application of insulin-like growth factor binding protein 5 in promotion of periodontal tissue regeneration
  • Application of insulin-like growth factor binding protein 5 in promotion of periodontal tissue regeneration

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Experimental program
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Effect test

Embodiment 1

[0031] (1) IGFBP5 expression decreased in gingival crevicular fluid of patients with periodontitis

[0032] The gingival crevicular fluid of normal and periodontitis patients was collected clinically, and the expression of IGFBP5 was detected by enzyme-linked immunosorbent assay. It was found that the expression of IGFBP5 in gingival crevicular fluid of patients with periodontitis decreased.

[0033] The inclusion criteria for the chronic periodontitis group were ① patients diagnosed with chronic periodontitis had a probing depth ≥ 4 mm and attachment loss ≥ 1 mm; ② the normal range of body mass index 18.5 ≤ body mass index ≤ 24. Exclusion criteria: ① people with related systemic diseases, including hypertension, diabetes, cardiovascular disease and other immune diseases; ② smokers; ③ history of periodontal system treatment within six months, including supragingival scaling and root planing surgery, periodontal surgery, etc.; ④ pregnant women, postmenopausal women and those ta...

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Abstract

The invention discloses an application of insulin-like growth factor binding protein 5 (IGFBP5) in promotion of mesenchymal stem cell induced periodontal tissue regeneration.

Description

technical field [0001] The invention relates to the technical field of stem cells, in particular to the application of insulin-like growth factor binding protein 5 in promoting periodontal tissue regeneration. Background technique [0002] Periodontitis is a multifactorial chronic inflammatory disease, clinically manifested as loss of periodontal support tissue, including periodontal ligament, cementum, alveolar bone , found that the interaction between host immune response, environmental factors and bacterial microbial factors is crucial in the occurrence, development and healing of periodontitis. The loss of alveolar bone and periodontal tissue damage caused by periodontitis is the primary cause of tooth loss in adults, which seriously affects the masticatory function, aesthetics and physical and mental health of patients. Traditional periodontal treatment methods mainly include mechanical removal methods, including supragingival scaling and subgingival scaling. Removing ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P1/02
Inventor 范志朋王松灵王月君刘大勇
Owner BEIJING STOMATOLOGY HOSPITAL CAPITAL MEDICAL UNIV
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