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46results about "Insulin-like growth factor binding protein" patented technology

IGF-binding protein-derived peptide or small molecule

InactiveUS6914049B2Reducing tumor invasivenessReducing and inhibiting vascular restenosisSenses disorderNervous disorderPeptideSmall molecule
New compositions based on IGF-binding protein sequences are provided. New tools for high-throughput research are provided. New methods for the treatment of human disease are provided. IGFBP-3-derived peptide or small molecule is administered to subjects having disease, thereby alleviating the symptoms of the disease.
Owner:BIOEXPERTISE +1

IGF-binding protein-derived peptide

InactiveUS6887851B2Reducing tumor invasivenessReducing and inhibiting vascular restenosisBiocidePeptide/protein ingredientsSmall moleculePeptide
New compositions based on IGF-binding protein sequences are provided. New tools for high-throughput research are provided. New methods for the treatment of human disease are provided. IGFBP-3-derived peptide or small molecule is administered to subjects having disease, thereby alleviating the symptoms of the disease.
Owner:ENMODULIN INC +1

Specifically-targeted swine IGFBP3 gene sgRNA targeting sequence and application

The invention relates to a sgRNA targeting sequence and application, in particular to a specifically-targeted swine IGFBP3 gene sgRNA targeting sequence and application. The sgRNA targeting sequence is CGTCTCGCGCTTGGACTCAG. By the sgRNA targeting sequence, an IGFBP3 gene can be knocked out or edited through a CTISPR / Cas9 system so as to eliminate IGFBP3 expression to lay the foundation for preparation of IGFBP3 transgenic swine. The specifically-targeted swine IGFBP3 gene sgRNA targeting sequence is applied to the field of gene engineering.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

IGF antagonist peptides

Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
Owner:GENENTECH INC

Antisense insulin-like growth factor binding protein (IGFBP)-2-oligodeoxynucleotides for prostate and other endocrine tumor therapy

InactiveUS7196067B2Reduce spreadDelay progression to androgen independenceSugar derivativesPeptide/protein ingredientsMammalAntisense oligodeoxynucleotides
Compositions and a method are provided for the treatment of prostate and other endocrine tumors in mammals, including humans, by administration of an antisense oligodeoxynucleotide (ODN) which is complementary to a portion of the gene encoding IGFBP-2. Using the Shionogi tumor model in vitro and in vivo, the administration of such an ODN was shown to reduce proliferation of tumor cells, and also to delay the progression to androgen independence. Thus, treatment of prostate and other hormone-regulated cancer in mammals, including humans, and delay of the progression of prostate tumors to androgen independence is accomplished by administering to the mammal a therapeutically effective amount of an antisense oligodeoxynucleotide which is complementary to a portion of the nucleic acid sequence encoding IGFBP-2 and which reduces the amount of IGFBP-2 in the treated cells.
Owner:THE UNIV OF BRITISH COLUMBIA

IGF antagonist peptides

Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
Owner:GENENTECH INC

Metal-binding therapeutic peptides

InactiveUS7611893B2Reduce the burden onEnhancing existing chemotherapeutic cocktailsOrganic active ingredientsSenses disorderLiving cellBiology
The present invention is related methods of delivering MBD peptide-linked agents into live cells. The methods described herein comprise contacting MBD peptide-linked agents to live cells under a condition of cellular stress. The methods of the invention may be used for therapeutic or diagnostic purposes.
Owner:ENMODULIN INC

IGF antagonist peptides

Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
Owner:GENENTECH INC

CCN3 peptide

InactiveUS20100004169A1Increase kinase activityActivity be increased and decreasedCompound screeningApoptosis detectionDiseasePeptide sequence
The present application relates to nucleic acid and peptide sequences of CCN3 and derivatives and fragments thereof useful in the treatment of disease, in particular tumours and / or for use as a clinical marker.
Owner:QUEENS UNIV OF BELFAST

IGF-I responsive gene and use thereof

A protein encoded by a gene comprises nucleic acid sequence SEQ ID No. 1, 2, 3, 4, 5, 6 or a derivative or mutant or fragment or variant or peptide thereof. The protein promotes the attachment and modulates the motility and invasion capability of cells.
Owner:UNIV COLLEGE CORK NAT UNIV OF IRELAND CORK

Methods for delivering MBD peptide-linked agent into cells under conditions of cellular stress

The present invention is related to methods of delivering MBD peptide-linked agents into live cells. The methods described herein comprise contacting MBD peptide-linked agents to live cells under a condition of cellular stress. The methods of the invention may be used for therapeutic or diagnostic purposes.
Owner:BIOEXPERTISE

Purified rhlGF-I/rhlGFBP-3 complexes and their method of manufacture

Complexes of IGF-I and IGFBP-3 with new levels of purity are provided. Chromatographic techniques have been developed that remove contaminants, such as mass and charge variants of IGFBP-3. The new techniques enable the production of high-quality pharmaceutical compositions comprising IGF-I / IGFBP-3 complexes.
Owner:INSMED INC

Identification and medical applications of Anti-citrullinated-protein antibodies in rheumatoid arthritis

Compositions and methods for detection of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients. Patient samples known or suspected of containing ACPAs were probed against citrullinated proteins, and antibody responses to 190 citrullinated proteins in 20 RA patients were investigated. Unique antibody reactivity patterns in both clinical anti-cyclic citrullinated peptide assay positive (CCP+) and negative (CCP−) RA patients were observed. At individual antigen levels, six novel antibody / antigen complexes were discovered and validated against specific citrullinated antigens (Myelin Basic Protein (MBP), osteopontin (SPP1), flap endonuclease (FEN1), insulin like growth factor binding protein 6 (IGFBP6), insulin like growth factor I (IGF1) and stanniocalcin-2 (STC2)) in RA patients. Identification of immune-dominant epitope(s) for citrullinated MBP was also performed. The identified biomarkers have high specificity, especially MBP.
Owner:ARIZONA STATE UNIVERSITY +1

Cxcl12 (chemokine (c-x-c motif) ligand 12) and igfbp2 inhibitors for the application in the treatment of diabetes mellitus associated pancreatic cancer

The subject of the invention is the application of CXCL12 (Chemokine (C-X-C motif) Ligand 12) and IGFBP2 inhibitors for the treatment of diabetes mellitus associated pancreatic cancer. The core of this invention is the discovery that the chronically increased glucose levels (chronic hyperglycemia) could may an important role in the development of the pancreatic cancer and that the development of the pancreatic cancer due to chronic hyperglycemia or an already developed pancreatic cancer may be prevented / inhibited / delayed by the inhibition of CXCL12 and IGFBP2. In addition the subject of the invention is the production of inhibitors for the application as a treatment of diabetes mellitus associated pancreatic cancer and pharmaceutical drugs containing the inhibitors.
Owner:FIRNEISZ GABOR +2

Method for treating cartilage disorders

The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
Owner:GENENTECH INC

Inhibitors and Use Thereof in Cancer Treatment

The invention generally relates to inhibitors of DNA double strand break (DSB) repair in cancer cells exposed to DNA-damaging chemotherapy drugs or radiotherapy. In particular, agents that inhibit binding between insulin-like growth factor binding protein-3 (IGFBP-3) and non-POU (pituitary-specific Pit-1, octamer-binding proteins Oct-1 and Oct-2, and neural Unc-86) domain-containing octamer-binding protein (NONO) and methods of using such agents to enhance chemosensitivity or radiosensitivity in cancer treatment are disclosed.
Owner:THE UNIV OF SYDNEY

IGF-binding protein-derived peptide or small molecule

New compositions based on IGF-binding protein sequences are provided. New tools for high-throughput research are provided. New methods for the treatment of human disease are provided. IGFBP-3-derived peptide or small molecule is administered to subjects having disease, thereby alleviating the symptoms of the disease.
Owner:BIOEXPERTISE

Mutants of IGF Binding Proteins and Methods of Production of Antagonists Thereof

The present invention provides a crystal suitable for X-ray diffraction, comprising a complex of insulin-like growth factor I or II (IGF) and a polypeptide consisting of the amino acids 40-92 of IGFBP-5 or a fragment thereof consisting at least of the 9th to 12th cysteine of IGFBP-5 methods for the determination of the atomic coordinates of such a crystal; IGFBP mutants with enhanced binding affinity for IGF-I and / or IGF-II, and methods to identify and optimize small molecules which displace IGFs from their binding proteins.
Owner:BEISEL HANS GEORG +7
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