A kind of preparation method of chitosan-based wound dressing of aromatic antibacterial

A wound dressing and chitosan technology, applied in the field of medical materials, can solve the problems of short antibacterial action time, reduce the concentration of essential oils, affect the efficacy of sterilization, etc., achieve significant antibacterial effect, optimize the environment, and pleasant mood effects.

Inactive Publication Date: 2017-06-09
济南科乐医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dressing adopts a dissolution-type bactericidal mechanism, and the release of plant essential oil components makes the antibacterial effect time shorter
Diffusion into the wound exudate may reduce the concentration of essential oils and affect the efficacy of sterilization

Method used

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  • A kind of preparation method of chitosan-based wound dressing of aromatic antibacterial
  • A kind of preparation method of chitosan-based wound dressing of aromatic antibacterial
  • A kind of preparation method of chitosan-based wound dressing of aromatic antibacterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A kind of preparation method of chitosan-based wound dressing of aromatic antibacterial:

[0044] (1) Tea tree essential oil, menthol and Artemisia argyi essential oil were stirred at 60 rpm at 4°C in a mass ratio of 1:1:1. Add 8g of sodium chloride, 0.2 g / L of potassium chloride, 1.44g of disodium hydrogen phosphate, and 0.24g of dipotassium hydrogen phosphate into 800ml of water, stir to fully dissolve, adjust the pH value to 6.5 with hydrochloric acid, and add water to 1000ml , Add 60g Tween 80 to obtain a phosphate buffer solution. Add the essential oil mixture to the phosphate buffer solution at a concentration of 1g / 100mL to obtain the natural aromatic antibacterial agent;

[0045] (2) Dissolve 100mg of soybean lecithin and 25mg of cholesterol in chloroform and pour it into a round-bottomed flask, and rotate it at room temperature until a uniform film is formed on the wall of the bottle; dissolve 10ml of natural aromatic antibacterial agent in an ultrasonic water...

Embodiment 2

[0049] A kind of preparation method of chitosan-based wound dressing of aromatic antibacterial:

[0050] (1) Tea tree essential oil, menthol and Artemisia argyi essential oil were stirred at 60 rpm at 4°C in a mass ratio of 1:1:1. Add 8g of sodium chloride, 0.2 g / L of potassium chloride, 1.44g of disodium hydrogen phosphate, and 0.24g of dipotassium hydrogen phosphate into 800ml of water, stir to fully dissolve, adjust the pH value to 6.5 with hydrochloric acid, and add water to 1000ml , Add 60g Tween 80 to obtain a phosphate buffer solution. Add the essential oil mixture to the phosphate buffer solution at a concentration of 0.2g / 100mL to obtain the natural aromatic antibacterial agent;

[0051] (2) Dissolve 100mg of soybean lecithin and 25mg of cholesterol in chloroform and pour it into a round-bottomed flask, and rotate it at room temperature until a uniform film is formed on the wall of the bottle; dissolve 10ml of natural aromatic antibacterial agent in an ultrasonic wat...

Embodiment 3

[0055] A kind of preparation method of chitosan-based wound dressing of aromatic antibacterial:

[0056] (1) Tea tree essential oil, menthol and Artemisia argyi essential oil were stirred at 60 rpm at 4°C in a mass ratio of 1:1:1. Add 8g of sodium chloride, 0.2 g / L of potassium chloride, 1.44g of disodium hydrogen phosphate, and 0.24g of dipotassium hydrogen phosphate into 800ml of water, stir to fully dissolve, adjust the pH value to 6.5 with hydrochloric acid, and add water to 1000ml , Add 60g Tween 80 to obtain a phosphate buffer solution. Add the essential oil mixture to the phosphate buffer solution at a concentration of 2g / 100mL to obtain a natural aromatic antibacterial agent;

[0057] (2) Dissolve 100mg of soybean lecithin and 25mg of cholesterol in chloroform and pour it into a round-bottomed flask, and rotate it at room temperature until a uniform film is formed on the wall of the bottle; dissolve 10ml of natural aromatic antibacterial agent in an ultrasonic water b...

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Abstract

The invention discloses a preparation method for aromatic and bacteriostatic chitosan-based wound dressing. The preparation method comprises the following steps: mixing tea tree essential oil, menthol and folium artemisiae argyi essential oil according to a certain proportion to obtain a natural aromatic bacteriostatic agent; coating lipidosome with the natural aromatic bacteriostatic agent to obtain aromatic and bacteriostatic lipidosome; dispersing the aromatic and bacteriostatic lipidosome into a chitosan-sodium alginate-gelatin solution, and performing freeze drying according to certain process to obtain the aromatic and bacteriostatic chitosan-based wound dressing. The aromatic and bacteriostatic chitosan-based wound dressing is of a porous structure and efficient in bacteria capturing effect, lasting, broad-spectrum, efficient and antibacterial, good in slow release and antibacterial performance, hemostasis, water absorption and gas permeability and good in biocompatibility, has certain mint flavor, and has obvious curative effect in large wounds and burns.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of an aromatic antibacterial chitosan-based wound dressing. Background technique [0002] Chitosan is a natural macromolecule biological polysaccharide chitin deacetylation product, has excellent solvent resistance and alkali resistance, good biocompatibility and skin affinity, antibacterial, film-forming, breathable, It has good water absorption and moisturizing properties, can stop bleeding, promote wound healing, etc., and can be used as a medical material. However, due to the high brittleness and poor mechanical properties of chitosan, its use alone is limited. At present, there are a large number of literature reports that chitosan and other polymers are blended and modified to prepare dressing films with excellent properties. [0003] Tea tree essential oil is an oily extract obtained from the leaves of Melaleuca alternifolia thr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/46
Inventor 葛彦汤佳鹏唐虹王芳芳张陈成
Owner 济南科乐医药有限公司
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