Brivaracetam orally-disintegrating tablets and preparation method thereof
A technology of disintegrating tablet and disintegrating agent, which is applied in the field of brivaracetam orally disintegrating tablet and its preparation, can solve the problems of poor compliance, blockage of trachea, disappearance of muscle tension, etc., and achieves good disintegration performance, easy operation, and easy medication Effect
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[0019] Example 1
[0020] A Buwaxitan orally disintegrating tablet, which is made of the following components in parts by weight: 23 parts of Buwaxitam, 21.6 parts of microcrystalline cellulose, 32 parts of mannitol, 19 parts of lactose, and anhydrous citric acid 0.8 parts, 8 parts of cross-linked polyvinylpyrrolidone, 1.5 parts of sucralose, 0.5 parts of menthol, 1.3 parts of micronized silica gel, and 0.4 parts of sodium stearyl fumarate. The Buwaxitan orally disintegrating tablets are made by the following steps: weigh the components according to the formula, mix them evenly, and then use the freeze-drying method to prepare the product; the freeze-drying method is specifically as follows: 1) Preparation of liquid medicine: take The prescription amount of the drug is added to water to make a drug solution; 2) Pre-freezing: Pre-freezing the drug solution at a temperature of -40°C for 12 hours; 3) Sublimation: Under the conditions of a vacuum of 1.05 mbar and a partition temperat...
Example Embodiment
[0021] Example 2
[0022] A Buwaxitam orally disintegrating tablet, which is made of the following components in parts by weight: 18 parts of Buwaxitam, 26 parts of microcrystalline cellulose, 20 parts of mannitol, 25 parts of lactose, and anhydrous citric acid 0.5 parts, 10 parts of cross-linked polyvinylpyrrolidone, 0.75 parts of sucralose, menthol 1, 0.5 parts of micronized silica gel, and 1.5 parts of sodium stearyl fumarate. The preparation method is the same as in Example 1.
Example Embodiment
[0023] Example 3
[0024] A Buwaxitan orally disintegrating tablet, which is made of the following components in parts by weight: 32 parts of Buwaxitam, 26 parts of microcrystalline cellulose, 40 parts of mannitol, 10 parts of lactose, and anhydrous citric acid 1 part, 2 parts of cross-linked polyvinylpyrrolidone, 2 parts of sucralose, 0.2 parts of menthol, 2.5 parts of micronized silica gel, and 0.2 parts of sodium stearyl fumarate. The preparation method is the same as in Example 1.
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