Intraspinal anesthetic and preparation method and application thereof

An anesthetic and spinal canal technology, which is applied in the field of intraspinal anesthetic and its preparation, can solve problems such as discomfort and increase the economic cost of patients, and achieve the effects of restraining restlessness, avoiding adverse reactions, and preventing nerve damage and low back pain.

Active Publication Date: 2015-08-05
宋兴荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, local anesthetics used in spinal anesthesia cannot produce sedative effects, and patients will feel uncomfortable due to fear during surgery. At this time, intravenous compound sedative drugs are needed to complete comfortable anesthesia, which increases the economic cost of patients.

Method used

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  • Intraspinal anesthetic and preparation method and application thereof
  • Intraspinal anesthetic and preparation method and application thereof
  • Intraspinal anesthetic and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The spinal anesthetic of the present invention includes dexmedetomidine, epinephrine, betamethasone, and water for injection. Neuraxial anesthetics per milliliter include dexmedetomidine 1 μg, epinephrine 1 μg, and betamethasone 200 μg.

[0036] The preparation method of intraspinal anesthetic of the present invention may further comprise the steps:

[0037] (1) After mixing 2000 μg of betamethasone and 10 μg of epinephrine, add 5 ml of sterilized water for injection, and then, on a constant temperature oscillator in a water bath, keep the temperature at 37° C., the oscillation frequency at 150 rpm, and oscillate for 20 minutes to mix evenly;

[0038] (2) Add 10 μg of dexmedetomidine to the mixed solution in step (1), then add sterilized water for injection to 10 ml, and place on a constant temperature oscillator in a water bath at a constant temperature of 37° C., with an oscillation frequency of 150 rpm, and oscillate for 20 minutes; Then lower to a constant temperat...

Embodiment 2

[0045] The spinal anesthetic of the present invention includes dexmedetomidine, epinephrine, betamethasone, and water for injection. Neuraxial anesthetics per milliliter include 2 μg of dexmedetomidine, 2 μg of epinephrine, and 400 μg of betamethasone.

[0046] The preparation method of intraspinal anesthetic of the present invention may further comprise the steps:

[0047] (1) After mixing 4000 μg of betamethasone and 20 μg of epinephrine, add 5 ml of sterilized water for injection, and then, on a constant temperature shaker in a water bath, keep the temperature at 37°C and the oscillation frequency at 150 rpm, and oscillate for 20 minutes to mix evenly;

[0048] (2) Add 20 μg of dexmedetomidine to the mixed solution in step (1), then add sterilized water for injection to 10 ml, and place on a constant temperature oscillator in a water bath at a constant temperature of 37° C., with an oscillation frequency of 150 rpm, and oscillate for 20 minutes; Then lower to a constant temp...

Embodiment 3

[0058] The spinal anesthetic of the present invention includes dexmedetomidine, epinephrine, betamethasone, and water for injection. Neuraxial anesthetics per milliliter include 3 μg of dexmedetomidine, 3 μg of epinephrine, and 600 μg of betamethasone.

[0059] The preparation method of intraspinal anesthetic of the present invention may further comprise the steps:

[0060] (1) After mixing 6000 μg of betamethasone and 30 μg of epinephrine, add 5 ml of sterilized water for injection, and then, on a constant temperature shaker in a water bath, keep the temperature at 37°C and the oscillation frequency at 150 rpm, and oscillate for 20 minutes to mix evenly;

[0061] (2) After adding 30 μg of dexmedetomidine to the mixed solution in step (1), add sterilized water for injection to 10 ml, and place on a constant temperature oscillator in a water bath at a constant temperature of 37° C., with an oscillation frequency of 150 rpm, and oscillate for 20 minutes; Then lower to a constan...

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Abstract

The invention discloses an intraspinal anesthetic and a preparation method and an application thereof. The intraspinal anesthetic comprises dexmedetomidine, epinephrine, betamethasone and water for injection. The preparation method comprises the following steps: (1) after the betamethasone and the epinephrine are mixed and 50% of water for injection of the full dose are added, uniformly mixing; (2) after the dexmedetomidine is mixed in a mixing solution in step (1), adding the water for injection to full dose, and uniformly mixing; (3) filtrating and sterilizing the mixing solution in step (2) to obtain the intraspinal anesthetic. The invention further provides the application of the intraspinal anesthetic in the preparation of the intraspinal anesthetic. According to the intraspinal anesthetic provided by the invention, the neurovirulent effect caused by using local anesthetics to the intraspinal anesthesia can be prevented; furthermore, the intraspinal anesthetic has the effects of analgesia, calm, muscle relaxation and adverse areflexia and shiver prevention, can evade the adverse effects of the vein use and can be used for special patients.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of anesthetics, and in particular relates to a spinal anesthetic and its preparation method and application. Background technique [0002] The existing intraspinal anesthesia is to inject local anesthetics into different cavities in the spinal canal, and the spinal nerve roots affected by the drugs are blocked or temporarily paralyzed, so that the corresponding areas dominated by the spinal nerves produce anesthesia, mainly including spinal anesthesia, Epidural anesthesia, which also includes sacral anesthesia. In the history of development, use and improvement of local anesthetics in the past 80 years, due to the irreplaceable role of local anesthetics, patients are forced to bear their neurotoxic effects, and anesthesiologists and scientific researchers have always been committed to the mechanism and mechanism of local anesthetic toxicity. However, unfortunately, all the cur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61P23/02A61P43/00A61K31/4174A61K31/137
Inventor 宋兴荣
Owner 宋兴荣
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