High-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in organism

A technology for implanting materials and organisms, applied in the field of high-strength, toughness, and corrosion-resistant magnesium alloys, can solve non-degradable problems, achieve the effects of avoiding neurotoxicity, avoiding pain and trouble, and satisfying biocompatibility

Active Publication Date: 2013-01-09
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problems caused by the non-degradability of the current clinical metal implant materials in the body, and considers the shortcomings of the current degradable magnesium alloy as the implant material in terms of mechanical properties, corrosion properties, and biological safety. It has excellent mechanical properties, ideal corrosion resistance, and good biocompatibility, and is suitable for stents for vascular interventional therapy and degradable bone plates, bone nails and other orthopedic implant materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Mg-Nd-Zn-Ag-Zr magnesium alloy ingot prepared by semi-continuous casting Among them, the alloy elements are 1.0% Nd, 0.1% Zn, 0.1% Ag, 0.3% Zr, and the rest are magnesium. The purity of magnesium in the raw material is 99.99%, the purity of Zn is 99.999%, and the purity of silver is 99.99%. Nd and Zr were added in the form of Mg-30%Nd and Mg-30%Zr binary master alloys, respectively. Cut a certain length of ingot, after 10h solution treatment at 540℃, extrude into The round bar is extruded at 450°C. High plasticity and medium strength magnesium alloy (tensile strength is 228MPa, yield strength is 167MPa, elongation is 38%) can be obtained under this process. The corrosion rate of the material in simulated body fluid environment is 0.22mm / year. Biological test results show that the material has no obvious cytotoxicity and good blood compatibility. It can meet the requirements of intravascular stent materials.

Embodiment 2

[0024] Mg-Nd-Zn-Ag-Zr magnesium alloy ingot prepared by semi-continuous casting Among them, the alloy elements are 2.7% Nd, 0.2% Zn, 0.2% Ag, 0.4% Zr, and the rest are magnesium. The purity of magnesium in the raw material is 99.99%, the purity of Zn is 99.999%, and the purity of silver is 99.99%. Nd and Zr were added in the form of Mg-30%Nd and Mg-30%Zr binary master alloys, respectively. Cut a certain length of ingot, after 10h solution treatment at 540℃, extrude into The round bar is extruded at 450°C. The high plasticity medium strength magnesium alloy (the tensile strength is 260MPa, the yield strength is 221MPa, and the elongation is 32%) can be obtained under this process. The corrosion rate in the simulated body fluid environment is 0.25mm / year. Biological test results show that the material has no obvious cytotoxicity and good blood compatibility. It can meet the requirements of intravascular stent materials.

Embodiment 3

[0026] Mg-Nd-Zn-Ag-Zr magnesium alloy ingot prepared by semi-continuous casting Among them, the alloy elements are 3.2% Nd, 0.3% Zn, 0.3% Ag, 0.5% Zr, and the rest are magnesium. The purity of magnesium in the raw material is 99.99%, the purity of Zn is 99.999%, and the purity of silver is 99.99%. Nd and Zr were added in the form of Mg-30%Nd and Mg-30%Zr binary master alloys, respectively. Cut a certain length of ingot, after 10h solution treatment at 540℃, extrude into The round bar is extruded at 350°C, and then subjected to aging treatment. The aging process is 300°C, and the heat preservation time is 10h. A high-strength, medium-plastic magnesium alloy (with a tensile strength of 320MPa, a yield strength of 309MPa and an elongation of 16%) can be obtained under the process. The corrosion rate in the simulated body fluid environment is 0.26mm / year. Biological test results show that the material has no obvious cytotoxicity and good blood compatibility. It can meet the...

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Abstract

Disclosed is a magnesium alloy used for degradable stent material in vivo and preparation method thereof. The components and their weight ratio of magnesium alloy are: Nd 1-2.49%, Zn 0.1-2%, Zr 0-0.6%, impurities 0-0.2% and balance Mg. The magnesium alloy has better mechanical property and plastic deformation property than WE43, desired uniform corrosion resistance and good biocompatibility. The magnesium alloy can be applied to prepare lumen support which is used for short-term intervention therapeutic of vessel, biliary duct, pancreatic duct, and esophagus and so on.

Description

technical field [0001] The invention relates to a biomedical high-strength, toughness, and corrosion-resistant magnesium alloy, specifically, a high-strength, toughness, and corrosion-resistant magnesium alloy that is suitable as a biodegradable implant material. Background technique [0002] Among the orthopedic implant materials currently used clinically, stainless steel and titanium alloys have become widely used materials due to their good biocompatibility, corrosion resistance and mechanical properties. However, a common problem in existing metal implant materials such as stainless steel and titanium alloy is poor mechanical compatibility with biological bone. The tensile strength of stainless steel, titanium alloy, etc. is more than 5 times higher than that of natural bone, and the elastic modulus is more than 10 times higher. Such materials can produce a great "stress shielding" effect on local bone tissue after being implanted in the human body. Due to the decrease...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/50A61L31/02A61L31/14
CPCA61L2430/02C22C23/04A61L27/58A61L27/047C22C23/06C22F1/06
Inventor 袁广银章晓波丁文江
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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