35results about How to "Avoid neurotoxicity" patented technology

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease.

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of Δ6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain inflammatory disorders and chronic degenerative diseases characterized by neuronal loss and chronic pain including neuropathic pain.

Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a β amyloid peptide, preferably a retro-inverso isomer of Aβ17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an acetate group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.

The use of a compound of formula (I), is disclosed in treating and / or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.

The embodiment of the invention provides a corrosion-resistant high strength and toughness magnesium alloy tubular product and a preparation process. The alloy tubular product is prepared from the following elements in percent by mass: 1.0-6.0% of Nd, 0.1-5.0% of Zn, 0.1-5.0% of Ca, 0.1-4.0% of Zr and the balance Mg. The preparation process comprises the following steps: successively preparing a magnesium alloy cast ingot, a magnesium alloy blank, a magnesium round bar and a magnesium hollow round ingot through a series of steps: vacuum semicontinuous casting, solid solution homogenizing, barextrusion processing, hollow round ingot processing and the like; and finally, extruding the hollow round ingot to obtain the corrosion-resistant high strength and toughness magnesium alloy tubular product. The corrosion-resistant high strength and toughness magnesium alloy tubular product solves the problem of hard plastic processing for preparing a bracket as the magnesium alloy tubular productis relatively poor in deformability at room temperature in the prior art, can be degraded uniformly in vivo while achieving an ideal supporting effect of the alloy, and meanwhile, has better corrosionresistance and is relatively uniform to corrode, wherein the corrosion rate is 0.18-0.42 mm / year.

Disclosed is a magnesium alloy used for degradable stent material in vivo and preparation method thereof. The components and their weight ratio of magnesium alloy are: Nd 1-2.49%, Zn 0.1-2%, Zr 0-0.6%, impurities 0-0.2% and balance Mg. The magnesium alloy has better mechanical property and plastic deformation property than WE43, desired uniform corrosion resistance and good biocompatibility. The magnesium alloy can be applied to prepare lumen support which is used for short-term intervention therapeutic of vessel, biliary duct, pancreatic duct, and esophagus and so on.

The invention discloses a spinal canal anesthetic and its preparation method and application. The spinal canal anesthetic comprises dexmedetomidine, epinephrine, betamethasone and water for injection. The preparation method comprises the following steps: (1) after mixing betamethasone and epinephrine, adding 50% of the total amount of water for injection, and mixing uniformly; (2) adding dexmedetomidine to the mixed solution in step (1) , then add water for injection to the full amount, and mix evenly; (3) filter and sterilize the mixed solution in step (2) to obtain. The present invention also proposes the application of the spinal canal anesthetic in the preparation of spinal canal anesthetic drugs. The intraspinal anesthetic of the present invention avoids the neurotoxic effect caused by local anesthetics used in intraspinal anesthesia, has the effects of analgesia, sedation, muscle relaxation, and disappearance of adverse reflexes, and prevents shivering, and can avoid the adverse reactions of its intravenous use , can also be used for special patients.

The embodiment of the invention provides high-strength-and-toughness and corrosion-resistance magnesium alloy and a preparation method thereof. The alloy solves the problems in the prior art that thedeformation capability of the magnesium alloy is poorer and the plasticity processing is difficult when the magnesium alloy is used for preparing stents, the stents can be uniformly degraded in the body while the ideal supporting effect of alloy is achieved, better corrosion resistant performance is achieved, the corrosion-resistance rate is significantly reduced, and the corrosion is more uniform.

The invention provides a biomedical degradable anti-corrosion high strength and ductility magnesium alloy and a preparation method thereof. With the total weight of the magnesium alloy being 100%, thecomponents of the magnesium alloy comprise, by weight, 1.0-4.5% of Nd, 0.2-2.0% of Zn, 0-1.0% of Ca, 0-1.0% of Zr and the balance Mg. The preparation method of the magnesium alloy includes the stepsthat by adopting a mode of vacuum semi-continuous casting, a magnesium alloy cast ingot is prepared according to the components and the weight percentage of the magnesium alloy, then solid solution treatment and extrusion are conducted on the magnesium alloy cast ingot, and the magnesium alloy is prepared. The biomedical degradable anti-corrosion high strength and ductility magnesium alloy has theadvantages of being nontoxic, capable of being degraded completely, good in anti-corrosion property, high in strength and ductility and the like, and can be used for preparing intravascular stents.