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High-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in organism

A technology for implanting materials and organisms, applied in the field of high-strength, toughness, and corrosion-resistant magnesium alloys, can solve problems such as non-degradability, meet the requirements of biocompatibility, avoid pain and trouble, and achieve the effect of good mechanical properties

Active Publication Date: 2010-09-22
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problems caused by the non-degradability of the current clinical metal implant materials in the body, and considers the shortcomings of the current degradable magnesium alloy as the implant material in terms of mechanical properties, corrosion properties, and biological safety. It has excellent mechanical properties, ideal corrosion resistance, and good biocompatibility, and is suitable for stents for vascular interventional therapy and degradable bone plates, bone nails and other orthopedic implant materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Mg-Nd-Zn-Ag-Zr magnesium alloy ingots by semi-continuous casting Among them, the alloying elements are 1.0% Nd, 0.1% Zn, 0.1% Ag, 0.3% Zr, and the rest are magnesium. The purity of magnesium in the raw materials is 99.99%, the purity of Zn is 99.999%, and the purity of silver is 99.99%. Nd and Zr are added in the form of Mg-30% Nd and Mg-30% Zr binary master alloys. Cut a certain length of ingots, and extrude them after 540℃, 10h solution treatment The extruding temperature is 450℃. High-plasticity and medium-strength magnesium alloy can be obtained under this process (tensile strength is 228MPa, yield strength is 167MPa, and elongation is 38%). The corrosion rate of this material in a simulated body fluid environment is 0.22mm / year. The biological test results show that the material has no obvious cytotoxicity and good blood compatibility. It can meet the requirements of intravascular stent materials.

Embodiment 2

[0024] Preparation of Mg-Nd-Zn-Ag-Zr magnesium alloy ingots by semi-continuous casting Among them, the alloying elements are 2.7% Nd, 0.2% Zn, 0.2% Ag, 0.4% Zr, and the rest are magnesium. The purity of magnesium in the raw materials is 99.99%, the purity of Zn is 99.999%, and the purity of silver is 99.99%. Nd and Zr are added in the form of Mg-30% Nd and Mg-30% Zr binary master alloys. Cut a certain length of ingots, and extrude them after 540℃, 10h solution treatment The extruding temperature is 450℃. High-plasticity and medium-strength magnesium alloys (tensile strength of 260MPa, yield strength of 221MPa, and elongation of 32%) can be obtained under this process. The corrosion rate in the simulated body fluid environment is 0.25mm / year. The biological test results show that the material has no obvious cytotoxicity and good blood compatibility. It can meet the requirements of intravascular stent materials.

Embodiment 3

[0026] Preparation of Mg-Nd-Zn-Ag-Zr magnesium alloy ingots by semi-continuous casting Among them, the alloying elements are 3.2% Nd, 0.3% Zn, 0.3% Ag, 0.5% Zr, and the rest are magnesium. The purity of magnesium in the raw materials is 99.99%, the purity of Zn is 99.999%, and the purity of silver is 99.99%. Nd and Zr are added in the form of Mg-30% Nd and Mg-30% Zr binary master alloys. Cut a certain length of ingots, and extrude them after 540℃, 10h solution treatment The extruding temperature is 350℃, and then undergo aging treatment, the aging process is 300℃, and the heat preservation is 10h. High-strength medium-plastic magnesium alloy can be obtained under this process (tensile strength is 320MPa, yield strength is 309MPa, elongation is 16%). The corrosion rate in the simulated body fluid environment is 0.26mm / year. The biological test results show that the material has no obvious cytotoxicity and good blood compatibility. It can meet the requirements of bone plates...

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Abstract

The invention relates to a high-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in an organism, belonging to the technical field of biological materials. The material of the invention comprises the following components in percentage by weight: 1-4% of Nd, 0.1-1.0% of Zn, 0.1-1.0% of Ag, 0.3-0.8% of Zr and balance of Mg. The invention strengthens magnesium alloy through alloy elements, refines grains, improves plasticity, and further strengthens the magnesium alloy through extrusion deformation and heat treatment processes. The corrosion rate of the magnesium alloy provided by the invention in the simulated body fluid is 0.22-0.28mm / year, meeting the requirement of the implanted material for the corrosion rate; and the material of the invention does not have obvious cytotoxicity and has good blood compatibility, thereby meeting the requirements of the implanted material for biological compatibility. The high-plasticity medium-strength magnesium alloy provided by the invention can be used for support intravascular stent materials, and the high-strength medium-plasticity magnesium alloy provided by the invention can be used for implanted materials in orthopaedics.

Description

Technical field [0001] The invention relates to a biomedical high-strength, corrosion-resistant magnesium alloy, specifically, a high-strength, corrosion-resistant magnesium alloy suitable as a biodegradable internal implant material. Background technique [0002] Among the currently clinically used orthopedic implant materials, stainless steel and titanium alloys have become widely used materials with good biocompatibility, corrosion resistance and mechanical properties. However, a common problem in existing metal implant materials such as stainless steel and titanium alloy is the poor mechanical compatibility with biological bones. The tensile strength of stainless steel, titanium alloy, etc. is more than 5 times higher than that of natural bone, and the elastic modulus is more than 10 times higher. Such materials can have a great "stress shield" effect on local bone tissue after being implanted in the human body. Due to the decrease in stress stimulation of the basal bone, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/50A61L31/02A61L31/14
CPCA61L2430/02C22C23/04A61L27/58A61L27/047C22C23/06C22F1/06
Inventor 袁广银章晓波丁文江
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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