211results about How to "Easy clearance" patented technology

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

An amphibious vehicle achieves a stable ride, maneuverability, and high speed. The vehicle includes a hull having a “V” center portion with outboard sponsons. The sponsons reside between the front wheel wells and the rear wheels wells for improving lift and transition to planing. Shallow tunnels begin in rear portions of the front wheel wells and taper into the sponsons to release water trapped in the wheel wells. Inward facing turning edges also reside between the front and rear wheel wells and improve in-water handling. Wheels are retractable by pneumatic cylinders in parallel with air shock absorbers and suspension cutout in the hull allow the suspension to lower through the hull. Flaps reside under suspension members and rise to cover the suspension cutouts when the wheels are retractable when the wheels are raised to reduce drag. A Morse cable couple a rack and pinion unit to a jet drive.

Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein, R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, and tinnitus.

Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein-, R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7 are as defined herein. Such compounds are contemplated useful NI for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, and tinnitus.

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, tinnitus, and status epilepticus.

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, tinnitus, and status epilepticus.

The invention relates to a driving axle for electric motor-driven vehicles provided with at least one electric motor mounted on the axle and drive shafts driven by the motor shaft thereof with a planetary gear step inserted therebetween, connected to the output shafts bearing the wheels resting on the drive axle with a braking device and another planetary gear inserted therebetween. The invention is characterised in that two controlled asynchronous motors (10, 11) are disposed on the axle, said motors working separately and being controlled by a common control in the working functions thereof. The motor shafts (13) of both asynchronous motors (10, 11) are connected respectively by the planetary gear step (15, 16, 17) to the drive shaft (19) driving the downstream output shaft (24).

The present invention is based, at least in part on the discovery of therapeutic agents capable of preventing, inhibiting or modulating abnormal processing, misfolding or aggregation of protein. The therapeutic agents of the invention may prevent, inhibit or modulate the formation of inclusions. The therapeutic agents of the invention may also be capable of facilitating clearance and / or blocking the cellular toxicity of inclusions to treat or ameliorate disorders characterized by protein aggregation. Compounds which bind to structural motifs commonly found in protein aggregates, such as β-sheets, would represent strong candidates for such compounds and are therefore desirable.

Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein, , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5-to6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, and tinnitus.

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, tinnitus, status epilepticus.

A liquid tank is provided for a heavy vehicle, suitable for fastening to a vehicle frame by at least one supporting bracket having shaped surfaces arranged for load bearing and locating contact against the liquid tank. The tank includes two end face portions and a shell portion with a non-symmetrical cross-section extending there between. The tank includes a first, shaped portion facing the vehicle frame, arranged for load bearing contact against a first shaped surface of the supporting bracket, a second, shaped portion extending partially below the frame, arranged to locate the tank relative to a second shaped surface of the supporting bracket, and a third, substantially rectangular portion facing away from the vehicle frame, and that the tank is fastened to the bracket by at least one clamping means. A bracket for supporting such a tank is also disclosed.

The invention relates to a vehicle including a chassis and a pair of wheels supported in spaced apart relationship by the chassis for rotation about a common axis. A pair of drive modules is associated with the respective wheels. The drive modules and the chassis are connected for rotation as a sub-assembly relative to the wheels about the common axis with the centre of mass of the sub-assembly below the common axis in a static equilibrium position. Each of the drive modules is housed substantially within the respective wheel.

An elevator (20) includes a sill (38) that extends out from underneath an elevator car (30) to bridge an operating gap (26) between the car (30) and a landing (24). When an elevator door (34) is aligned with a landing door (36), the sill (38) extends outwardly from the car (30) until the sill (38) makes contact with a landing structure (40). A locking mechanism (52) securely locks the sill (38) to the landing structure (40). In one example, once proper sill alignment and locking engagement occurs, a door moving mechanism (50) is released and the elevator (34) and landing (36) doors open.

The invention relates to a device for adjusting the camber and / or toe of the wheels (20) of wheel suspensions (10), especially for motor vehicles, including a wheel carrier (12) on which the respective wheel (20) is rotatably mounted and which is subdivided into a carrier part (24) receiving the wheel, a guide part (22) connected to the wheel suspension (10), and two rotary parts, especially control cylinders (26, 28), arranged between the carrier part and the guide part and rotatable in relation to each other, to the carrier part (24) and to the guide part (22) about a common rotation axis (32). Each of the rotary parts can be moved by a drive (40) and a servo drive (42) in both directions of rotation. According to the invention, the servo drive (42) is designed for at least one of the rotary parts (26, 28) as a planetary gear train (42), and the planetary gear train (42) is especially radially externally arranged around the rotary part (26, 28).

A retractable ramp system for a mobility vehicle. A ramp platform is driven by a reversible motor, associated drive pulley, and drive belt affixed to a ramp carriage assembly. A spring-loaded mechanical release assembly is used to engage the drive pulley to the motor and to disengage the drive pulley from the motor. A manual control assembly is used for manual deployment of the ramp when the drive pulley is disengaged from the motor. The ramp flap provides a transition between the ramp platform and a mobility vehicle. The ramp flap is supported by wheels which translate along the ramp platform. Linear bearing blocks attach to pivot arms of the carriage assembly, which are in turn pivotably attached to the ramp platfom. Linear bearing blocks translate the ramp platform along guide shafts during deployment and stowage.

Truckin Board, a Recreational Board Vehicle with an elongated board, with a front and rear wheel trundle, truck assembly with eccentric friction roller brakes, activated by a spiral spring recoilable rope in a drum, pulling a cog into a lever, activating centrally pulled brakes between the wheels, which allows steering on an adjustable mount. A braking rope aids rider in staying on board while brakes are activated, while able to maintain helm control. Brake activator handle snaps back into board when not in use.

The invention discloses high-density self-compacted concrete and a preparation method. The high-density self-compacted concrete consists of the following components in percentage by mass: 15-32% of a cementing material, 20-35% of aggregates, 20-42% of sand, 3-12% of expanded vermiculite, 0.1-0.8 percentage of a water reducing agent, 0.04-0.5% of a thickening agent, 0.2-1.5% of a thixotropy lubricant, 0.08-0.8% of straw fiber and 10-25% of water. The preparation method comprises the following steps: stirring the cementing material, the straw fiber and the thickening agent needed for preparation for 3-6 minutes, sequentially adding the water, the water reducing agent and the thixotropy lubricant needed for preparation, and continuously stirring the mixture for 5-10 minutes so as to obtain a slurry mixed material; B, adding the aggregates, the sand and the expanded vermiculite into the slurry mixed material obtained in the step A, and stirring the mixture for 3-6 minutes, thereby obtaining the high-density self-compacted concrete. By adopting the high-density self-compacted concrete, properties of concrete can be effectively improved, a mixture can be relatively good in flowability and caking properties, and the high-density self-compacted concrete has the characteristics of being relatively good in anti-separation properties, tensile resistance, anti-cracking properties, self-filling properties, gap through properties, size stability and the like.

A liquid tank is provided for a heavy vehicle, suitable for fastening to a vehicle frame by at least one supporting bracket having shaped surfaces arranged for load bearing and locating contact against the liquid tank. The tank includes two end face portions and a shell portion with a non-symmetrical cross-section extending there between. The tank includes a first, shaped portion facing the vehicle frame, arranged for load bearing contact against a first shaped surface of the supporting bracket, a second, shaped portion extending partially below the frame, arranged to locate the tank relative to a second shaped surface of the supporting bracket, and a third, substantially rectangular portion facing away from the vehicle frame, and that the tank is fastened to the bracket by at least one clamping means. A bracket for supporting such a tank is also disclosed.

Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein, , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5- to 6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, and tinnitus.

The present invention relates to a windback device and method of use to prevent lubricant from leaking from a lubricant sump. More specifically, the present invention is comprised of a windback device within a lubricant sump formed from the coupling of an annular sump housing, an annular fluid seal assembly, and a bearing. The annular housing substantially surrounds the runner to form a chamber. The seal assembly is coupled to a sump housing both of which are adapted to receive a rotatable runner such that a sealed chamber is formed around the runner. A plurality of inclined threads extend along an inner face of the windback device and are angled such that lubricant or fluid splashed from the rotating shaft is redirected away from a shaft seal element of the annular fluid seal and through leak off slots leading to the sump housing chamber.

The invention relates to levamlodipine besylate crystals, a preparation method thereof and a brand-new medicinal composition containing the crystals. Characteristic peaks in an X-ray powder diffraction pattern obtained by measuring the levamlodipine besylate crystals by using Cu-K alpha rays are displayed as 8.0, 12.1, 15.4, 17.0, 19.8, 21.6, 23.0, 24.3, 25.7, 27.4, 30.7 and 33.5 degrees at 2 theta. The medicinal composition comprises the levamlodipine besylate crystals and pharmaceutically acceptable excipients, wherein the pharmaceutically acceptable excipients are microcrystalline cellulose, sodium starch glycolate and magnesium stearate. The crystals improve the dissolubility of levamlodipine besylate; and tablets prepared from the crystals have improved bioavailability.

A plenum fan comprising a fan wheel disposed within a box-like enclosure includes a secondary inlet cone, a primary inlet cone, and a flexible duct. The two inlet cones convey air to the mouth of the fan wheel. A frame supports the fan wheel and the primary inlet cone such that the frame, the fan wheel and the primary inlet cone comprise a fan assembly. If the fan assembly shifts due to fan thrust or vibration, the fan assembly moves as a unit. The flexible duct connects the primary inlet cone to an inlet of the enclosure while isolating the fan assembly's vibration from the enclosure. The secondary inlet cone extends from the inlet of the enclosure, protrudes into or toward the primary inlet cone and provides a smooth airflow path over the abrupt shape of the flexible duct.

Provided is a light source device capable of minimizing or preventing a decrease in amount of light emitted from portions in the vicinity of a locking member of a light guide plate, and capable of making intensity distribution in a plane of light emitted from the light guide plate uniform. The light source device includes a light guide plate 13 (13a, 13b) including a locking member 131a, 131b for disposition and fixing that is disposed on a peripheral portion of the light guide plate or disposed in a vicinity of the peripheral portion, anda light source (15a) capable of projecting light onto the peripheral portion, wherein the light that is projected from the light source onto portions of the light guiding plate, the portions being in the vicinity of the locking member, is higher in intensity than the light projected onto the other portions of the light guiding plate.

The present invention relates to a windback device and method of use to prevent lubricant from leaking from a lubricant sump. More specifically, the present invention is comprised of a windback device within a lubricant sump formed from the coupling of an annular sump housing, an annular fluid seal assembly, and a bearing. The annular housing substantially surrounds the runner to form a chamber. The seal assembly is coupled to a sump housing both of which are adapted to receive a rotatable runner such that a sealed chamber is formed around the runner. A plurality of inclined threads extend along an inner face of the windback device and are angled such that lubricant or fluid splashed from the rotating shaft is redirected away from a shaft seal element of the annular fluid seal and through leak off slots leading to the sump housing chamber.

In a manufacturing method of a semiconductor device, a substrate and a plurality of semiconductor chips stacked on the substrate are connected to each other by a ball bonding method adopting a reverse method. Specifically, after first bonding on a bonding pad on the substrate, a gold wire is led to a bonding pad of a semiconductor chip of the bottom layer, and by second bonding, a wire for connecting the substrate and the semiconductor chip of the bottom layer is formed. Similarly, other semiconductor chips are also connected to the substrate from the layer on the bottom. As a result, it is possible to reduce the package size, to provide a sufficient clearance between wires, and to reduce restrictions on combinations of semiconductor chips to be stacked.

An LED light fixture including a housing, a heat sink secured with respect to the housing and an LED illuminator secured with respect to the heat sink. The heat sink includes central and peripheral portions. The central portion has an LED-supporting surface and forward, rearward and lateral sides, the LED illuminator being at the LED-supporting surface. The peripheral portion extends laterally from the lateral sides. The central portion of the heat sink has downwardly-extending shield members at the lateral sides thereof configured and dimensioned to block illumination in a direction opposite the LED illuminator. In embodiments where the optical member is configured for directing emitter light predominantly toward the forward side, the central heat-sink portion has a downwardly-extending shield member at the rearward side thereof configured and dimensioned to block rearward illumination.

In a manufacturing method of a semiconductor device, a substrate and a plurality of semiconductor chips stacked on the substrate are connected to each other by a ball bonding method adopting a reverse method. Specifically, after first bonding on a bonding pad on the substrate, a gold wire is led to a bonding pad of a semiconductor chip of the bottom layer, and by second bonding, a wire for connecting the substrate and the semiconductor chip of the bottom layer is formed. Similarly, other semiconductor chips are also connected to the substrate from the layer on the bottom. As a result, it is possible to reduce the package size, to provide a sufficient clearance between wires, and to reduce restrictions on combinations of semiconductor chips to be stacked.