A kind of intraspinal anesthetic and its preparation method and application

An anesthetic and spinal canal technology, applied in the field of intraspinal anesthetic and its preparation, can solve the problems of increasing the economic cost and discomfort of patients, and achieve the effects of avoiding adverse reactions, suppressing agitation, and good sedative effect

Active Publication Date: 2017-12-29
宋兴荣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, local anesthetics used in spinal anesthesia cannot produce sedative effects, and patients will feel uncomfortable due to fear during surgery. At this time, intravenous compound sedative drugs are needed to complete comfortable anesthesia, which increases the economic cost of patients.

Method used

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  • A kind of intraspinal anesthetic and its preparation method and application
  • A kind of intraspinal anesthetic and its preparation method and application
  • A kind of intraspinal anesthetic and its preparation method and application

Examples

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Effect test

Embodiment 1

[0035] The spinal anesthetic of the present invention includes dexmedetomidine, epinephrine, betamethasone, and water for injection. Neuraxial anesthetics per milliliter include dexmedetomidine 1 μg, epinephrine 1 μg, and betamethasone 200 μg.

[0036] The preparation method of intraspinal anesthetic of the present invention may further comprise the steps:

[0037] (1) After mixing 2000 μg of betamethasone and 10 μg of epinephrine, add 5 ml of sterilized water for injection, and then, on a constant temperature oscillator in a water bath, keep the temperature at 37° C., the oscillation frequency at 150 rpm, and oscillate for 20 minutes to mix evenly;

[0038] (2) Add 10 μg of dexmedetomidine to the mixed solution in step (1), then add sterilized water for injection to 10 ml, and place on a constant temperature oscillator in a water bath at a constant temperature of 37° C., with an oscillation frequency of 150 rpm, and oscillate for 20 minutes; Then lower to a constant temperat...

Embodiment 2

[0045] The spinal anesthetic of the present invention includes dexmedetomidine, epinephrine, betamethasone, and water for injection. Neuraxial anesthetics per milliliter include 2 μg of dexmedetomidine, 2 μg of epinephrine, and 400 μg of betamethasone.

[0046] The preparation method of intraspinal anesthetic of the present invention may further comprise the steps:

[0047] (1) After mixing 4000 μg of betamethasone and 20 μg of epinephrine, add 5 ml of sterilized water for injection, and then, on a constant temperature shaker in a water bath, keep the temperature at 37°C and the oscillation frequency at 150 rpm, and oscillate for 20 minutes to mix evenly;

[0048] (2) Add 20 μg of dexmedetomidine to the mixed solution in step (1), then add sterilized water for injection to 10 ml, and place on a constant temperature oscillator in a water bath at a constant temperature of 37° C., with an oscillation frequency of 150 rpm, and oscillate for 20 minutes; Then lower to a constant temp...

Embodiment 3

[0058] The spinal anesthetic of the present invention includes dexmedetomidine, epinephrine, betamethasone, and water for injection. Neuraxial anesthetics per milliliter include 3 μg of dexmedetomidine, 3 μg of epinephrine, and 600 μg of betamethasone.

[0059] The preparation method of intraspinal anesthetic of the present invention may further comprise the steps:

[0060] (1) After mixing 6000 μg of betamethasone and 30 μg of epinephrine, add 5 ml of sterilized water for injection, and then, on a constant temperature shaker in a water bath, keep the temperature at 37°C and the oscillation frequency at 150 rpm, and oscillate for 20 minutes to mix evenly;

[0061] (2) After adding 30 μg of dexmedetomidine to the mixed solution in step (1), add sterilized water for injection to 10 ml, and place on a constant temperature oscillator in a water bath at a constant temperature of 37° C., with an oscillation frequency of 150 rpm, and oscillate for 20 minutes; Then lower to a constan...

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Abstract

The invention discloses a spinal canal anesthetic and its preparation method and application. The spinal canal anesthetic comprises dexmedetomidine, epinephrine, betamethasone and water for injection. The preparation method comprises the following steps: (1) after mixing betamethasone and epinephrine, adding 50% of the total amount of water for injection, and mixing uniformly; (2) adding dexmedetomidine to the mixed solution in step (1) , then add water for injection to the full amount, and mix evenly; (3) filter and sterilize the mixed solution in step (2) to obtain. The present invention also proposes the application of the spinal canal anesthetic in the preparation of spinal canal anesthetic drugs. The intraspinal anesthetic of the present invention avoids the neurotoxic effect caused by local anesthetics used in intraspinal anesthesia, has the effects of analgesia, sedation, muscle relaxation, and disappearance of adverse reflexes, and prevents shivering, and can avoid the adverse reactions of its intravenous use , can also be used for special patients.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of anesthetics, and in particular relates to a spinal anesthetic and its preparation method and application. Background technique [0002] The existing intraspinal anesthesia is to inject local anesthetics into different cavities in the spinal canal, and the spinal nerve roots affected by the drugs are blocked or temporarily paralyzed, so that the corresponding areas dominated by the spinal nerves produce anesthesia, mainly including spinal anesthesia, Epidural anesthesia, which also includes sacral anesthesia. In the history of development, use and improvement of local anesthetics in the past 80 years, due to the irreplaceable role of local anesthetics, patients are forced to bear their neurotoxic effects, and anesthesiologists and scientific researchers have always been committed to the mechanism and mechanism of local anesthetic toxicity. However, unfortunately, all the cur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61P23/02A61P43/00A61K31/4174A61K31/137
Inventor 宋兴荣
Owner 宋兴荣
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