Preparation method and applications of strongly-targeting multi-modal nanometer medicine

A nano drug and multi-modal technology, applied in the field of nano biomedicine, can solve the problems of poor targeting, achieve good targeting effect, enhance stability, and good biocompatibility

Inactive Publication Date: 2015-08-12
BEIJING UNIV OF TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome GNRmSiO in the prior art 2 To solve the problem of poor target...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and applications of strongly-targeting multi-modal nanometer medicine
  • Preparation method and applications of strongly-targeting multi-modal nanometer medicine
  • Preparation method and applications of strongly-targeting multi-modal nanometer medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of GNRmSiO2 core-shell structure carrier, specifically:

[0042] Purchase gold nanorod GNRs with a diameter of 10nm, a length of 39nm, and a longitudinal absorption peak of 780nm from Hong Kong Nanoseed Company. To 93μg / mL, obtain 20mL diluted gold nanorod solution; add 200μL of 0.1M NaOH solution, adjust the pH of the gold nanorod solution to between 10-11, and put it into a pre-set temperature (30°C) shaking Preheat in the container; prepare a methanol solution containing 20% ​​ethyl orthosilicate TEOS (purity 99.999%), divide into three times and add to the gold nanorod solution, each interval is 30 minutes, each time 60 μ L, this process needs to be in the shaker Shake slowly; after adding TEOS for the third time, adjust the oscillator to vigorous shaking, keep the temperature at 30 degrees Celsius, and shake for 1-2h; ultrasonically disperse the prepared sample (GNRmSiO2) and wash it once with methanol and ultrapure water respectively , and redispe...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method and applications of a strongly-targeting multi-modal nanometer medicine, and belongs to the field of nanometer biomedicine. According to the present invention, an antibody drug and a gold nanometer rod-mesoporous silica (GNR@mSiO2) core-shell structure carrier are conjugated by using a covalent method, wherein the antibody drug is conjugated on the carrier so as to provide the double functions of targeting property and drug treatment, such that the targeting property of the GNR@mSiO2 carrier is enhanced while the drug preparation process is simplified, and the whole nanometer medicine can precisely provide the effect at the lesion area without affecting the normal cells; and the nanometer medicine concurrently has multiple functions of targeting property, drug treatment, thermotherapy and the like, and further has multiple imaging functions of dual-photon fluorescence imaging, photoacoustic imaging, and the like, such that the detection on cancers and other diseases can be achieved, and the imaging-mediated treatment process can be completed.

Description

technical field [0001] The invention relates to a preparation method and application of a strongly targeted multimodal nano-medicine, belonging to the field of nano-biomedicine. Background technique [0002] Cancer is a disease with a high mortality rate, which has attracted widespread attention. Traditional cancer treatment methods include: chemotherapy, radiotherapy, and surgical resection. These methods have certain curative effects, but they all have immeasurable side effects on patients. Such as chemotherapy and radiotherapy, while killing cancer cells, they may also kill normal immune cells, reducing the body's immunity, and cancer cells have a certain memory function for this treatment method, while surgery has a certain degree of invasiveness. Compared with these traditional methods, photothermal therapy has significant advantages such as non-organized memory, good repeatability, and non-invasiveness, and is a hot field of current research. Photothermal therapy bel...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/48A61K39/395A61K9/14A61P35/00A61K49/00
Inventor 王秀红曹菲
Owner BEIJING UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap