In-vitro simulated dissolution and continuous on-line detection device and method for nicotine in bagged oral tobacco products

A tobacco product, in vitro simulation technology, applied in the direction of color/spectral characteristic measurement, etc., can solve the problems of expensive equipment and long cycle, and achieve the effect of simple detection method, continuous online detection, and stable color reaction

Active Publication Date: 2015-08-12
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, in the prior art, the in vitro experiments conducted for the research on the release of nicotine in buccal smokeless tobacco products are all off-line measurements, that is, the release liquid of buccal smokeless tobacco products is collected for a certain period of time and passed through After some pretreatment methods, use high-performance liquid chromatography or gas chromatography to quantitatively analyze the components in the released liquid; this detection method requires a long period of time for the entire detection process, and the instruments used are relatively expensive

Method used

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  • In-vitro simulated dissolution and continuous on-line detection device and method for nicotine in bagged oral tobacco products

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Experimental program
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Embodiment 1

[0033] like figure 1The device for in vitro simulated dissolution and continuous online detection of nicotine in pouched tobacco products, which includes: color developer storage device R1; dissolution agent storage device R2; located in the color developer storage device R1 The first peristaltic pump P1 downstream and connected to it through pipelines; the second peristaltic pump P2, dissolution tank A, decolorization column B, reaction tank R and spectrometer located downstream of the dissolution agent holding device R2 and connected in sequence through pipelines A photometer D; wherein the reaction pool R is also located downstream of the first peristaltic pump P1 and connected to it through a pipeline, and the spectrophotometer D is connected to the data processing device C. Downstream of the spectrophotometer D, a waste liquid collection device W connected to its liquid outlet may also be included. Wherein, the purpose of using the decolorizing column is to absorb the pi...

Embodiment 2

[0042] still use as figure 1 The detection device shown detects the nicotine content in the pouched snuff-type tobacco products, including the following steps:

[0043] (1) Weigh 0.35 g of homemade jasmine tea-flavored bag-packed buccal tobacco product, and dissolve it with a dissolution agent that can dissolve nicotine therein to obtain the first nicotine dissolution solution; wherein the dissolution agent is artificial saliva, Including the following components: 0.04wt% KCl, 0.04wt% NaCl, 0.06wt% CaCl 2 , 0.06wt% NaH 2 PO 4 , 0.0005wt% Na 2 The urea of ​​S, 0.1wt%; The pH of described stripping agent is 6.7;

[0044] (2) decolorizing the first nicotine eluate through a decolorization column to obtain a decolorized second nicotine eluate; wherein the decolorization column is a graphite carbon black-amino double-layer solid-phase extraction column;

[0045] (3) Add a color developing agent to the second nicotine eluting liquid to obtain a third nicotine eluting liquid; wh...

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Abstract

The invention relates to an in-vitro simulated dissolution and continuous online detection device for nicotine in bagged oral tobacco products. The device comprises a color developing agent containing device (R1), a dissolution agent containing device (R2), a first peristaltic pump (P1), a second peristaltic pump (P2), a dissolution pool (A), a decolorizing column (B), a reaction pool (R) and a spectrophotometer (D), wherein the first peristaltic pump (P1) is positioned at the downstream of the color developing agent containing device (R1) and is connected with the color developing agent containing device (R1) by virtue of a pipeline; the second peristaltic pump (P2), the dissolution pool (A), the decolorizing column (B), the reaction pool (R) and the spectrophotometer (D) are positioned at the downstream of the dissolution agent containing device (R2) and are sequentially connected with one another; the reaction pool (R) is positioned at the downstream of the first peristaltic pump (P1) and is connected with the first peristaltic pump (P1) by virtue of a pipeline; and the spectrophotometer (D) is connected with a data processing device (C). The invention also relates to an in-vitro simulated dissolution and continuous online detection method for the nicotine in the bagged oral tobacco products. According to the detection device and method disclosed by the invention, the continuous on-line detection of in-vitro dissolution for the nicotine can be realized, the operation is convenient, and the detection is rapid.

Description

technical field [0001] The invention relates to the technical field of component determination of smokeless tobacco products, in particular to an in vitro simulated dissolution and continuous online detection device and detection method for nicotine in bagged and buccal tobacco products. Background technique [0002] Buccal smokeless tobacco products refer to tobacco products that can be used directly through the mouth without going through the combustion process. Compared with traditional cigarettes, buccal smokeless tobacco products mainly have the following advantages: First, they do not need to be ignited, which greatly reduces the content of tar and other harmful components produced by combustion, and are less harmful to the human body; Second, it does not produce second-hand smoke, does not affect the air quality in public places, and to a certain extent alleviates the contradiction between smoking demand and smoking ban in public places; need. Among them, the bagged...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31
Inventor 袁大林汤建国廖晓祥郑绪东孙志勇雷萍尚善斋李寿波韩敬美陈永宽李正风陈建华朱瑞芝蔡炳彪李航谭正兰
Owner CHINA TOBACCO YUNNAN IND
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