Rapid detection method for concentration process of Fructus Gardeniae extract liquor

A technology of concentration process and detection method, which is applied in the direction of measuring device, weighing by removing certain components, and material analysis by optical means, can solve the problems of time-consuming and labor-intensive, and achieve good stability, high stability, achieve simple effects

Inactive Publication Date: 2015-08-26
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the quality control of the post-extraction concentration process mainly relies on experience and traditional quality analysis methods, which is time-consuming and laborious. Therefore, the research and development of rapid and non-destructive determination methods for key quality control indicat

Method used

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  • Rapid detection method for concentration process of Fructus Gardeniae extract liquor
  • Rapid detection method for concentration process of Fructus Gardeniae extract liquor
  • Rapid detection method for concentration process of Fructus Gardeniae extract liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Establishment of a near-infrared quantitative analysis model for solid content and geniposide concentration using the partial least squares method

[0032] 1. Collection of samples of gardenia extract concentrate

[0033] During the concentration process of the gardenia extract, the temperature is controlled to be ≦70°C, the volume of each batch of liquid medicine is 500~600kg, and about 2 tons of n-butanol is recovered in each batch, which takes 8~9 hours and is sampled at intervals of 20~40 minutes. Samples were taken in ~10 minutes, each sample was about 10 mL, and each batch of samples was 16~38. 6 batches, 127 samples. All samples were collected from the same sampling port of the single-effect concentration tank.

[0034] 2. Determination of key indicators

[0035] (1) Determination of geniposide concentration

[0036] Chromatographic conditions: chromatographic column: Kromasil C18 (4.6×250 mm, 5 μm); mobile phase: acetonitrile (A) - 0.2% glacial ac...

Embodiment 2

[0053] Example 2: Establishing a near-infrared quantitative analysis model for solid content and geniposide concentration using the forward artificial neural network method

[0054] 1. Establishment of quantitative model of feedforward artificial neural network method

[0055] As mentioned above, after completing the determination of key indicators and spectral scanning of the concentrated samples of gardenia extract, 16 samples were randomly selected as the verification set prediction, and the remaining 111 samples were used as the calibration set. For the geniposide concentration and solid content, specific bands were selected (The quantitative model of geniposide concentration is at 6013~4793 cm -1 In the band, the quantitative model of solid content is at 5769~5677 cm -1 and 5893~5831 cm -1 band), after corresponding preprocessing of the spectral data of the samples in the calibration set (the quantitative calibration model of geniposide concentration is a combination of...

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Abstract

The invention provides a rapid detection method for concentration process of a Fructus Gardeniae extract liquor. The method is as below: collecting Fructus Gardeniae extract concentrated liquor samples of different batches in Reduning injection from large production; determining key indicators, including solid content and geniposide concentration, in the Fructus Gardeniae extract concentrated liquor; collecting near-infrared spectra of the Fructus Gardeniae concentrated liquor sample; selecting an appropriate spectrum pretreatment method and a modeling wave band; establishing near infrared quantitative calibration models of the solid content and geniposide concentration by using partial least squares method and forward artificial neural network respectively; evaluating model performance by using evaluation indexes for each model; importing validation data into a built calibration model to evaluate the predictive ability of the models. The invention introduces near infrared spectroscopy as a detection method for concentration process of Fructus Gardeniae extract liquor. The method can quickly detect changes in the the solid content and concentration of geniposide in the concentration process of Fructus Gardeniae extract liquor, meets the rapid and effective actual production requirements, and has broad application prospects.

Description

technical field [0001] The invention belongs to the field of near-infrared rapid detection, and in particular relates to a rapid detection method for the concentration process of gardenia extract. Background technique [0002] The main components of Reduning Injection are honeysuckle, Artemisia annua and Gardenia, and it has significant curative effect on influenza, acute upper respiratory tract infection, acute bronchitis, and respiratory medicine. The concentration process after extraction is one of the key processes in the production of Reduning, which is directly related to the change of the content of each component in Reduning. At present, the quality control of the post-extraction concentration process mainly relies on experience and traditional quality analysis methods, which is time-consuming and laborious. Therefore, the research and development of rapid and non-destructive determination methods for key quality control indicators in the concentration process of Red...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N5/04G01N21/3577G01N21/359
Inventor 刘雪松陶玲艳金叶陈勇吴永江萧伟王振中毕宇安
Owner ZHEJIANG UNIV
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