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An internal extraction electrospray ionization source and its mass spectrometry analysis method

An electrospray ionization source and extraction technology, which is applied in the field of analytical chemistry, can solve problems such as easy to change samples, complex analysis methods and device operations, and differences in the internal structure of tissue samples, so as to expand the application range, ensure stability and reliability , the effect of easy operation

Inactive Publication Date: 2017-04-05
EAST CHINA UNIV OF TECH +1
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] The invention provides an internal extraction electrospray ionization source and its mass spectrometry analysis method, which solves the technical problems that the analysis methods and devices in the prior art are complicated to operate, easy to change samples, and easily affected by differences in the internal structure of tissue samples

Method used

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  • An internal extraction electrospray ionization source and its mass spectrometry analysis method
  • An internal extraction electrospray ionization source and its mass spectrometry analysis method
  • An internal extraction electrospray ionization source and its mass spectrometry analysis method

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Embodiment Construction

[0019] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0020] Embodiments of the present invention provide an internal extraction electrospray ionization source device, such as figure 1 , Figure 1A , figure 2 , Figure 2A , image 3 As shown, it is composed of a sampler handle 11, a quantitative sampler 12, a capillary holder 13, a holder inner sleeve 14, an extractant capillary 15, a hand-twist joint 16 and an extractant channel 17, and the sampler handle 11 is connected to a quantitative The sampler 12 constitutes a sampling device. The quantitative sampler 12 , the capillary holder 13 , the inner sleeve of the holder 14 , the extractant capillary 15 and the fingertight joint 16 are sequentially connected and connected with the extractant channel 17 .

[0021] Wherein, the sam...

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Abstract

The invention relates to the field of analytical chemistry, and discloses an internal extraction electrospray ionization source and a mass spectrometry analysis method thereof. The internal extraction electrospray ionization source consists of a sampler handle 11, a quantitative sampler 12, a capillary holder 13, and an inner sleeve of the holder. Tube 14, extractant capillary 15, hand twist joint 16 and extractant passage 17 constitute, described sampler handle 11 and quantitative sampler 12 constitute sampling device, quantitative sampler 12, capillary tube holder 13, holder inner casing 14 , the extractant capillary 15 and the thumb joint 16 are sequentially connected and connected with the extractant passage 17. The invention guarantees the stability and reliability of the analysis results. The ionization source device has a built-in electrospray nozzle, which can be directly used to form electrospray after sampling, which is easy to operate and eliminates the influence caused by differences in texture or blood vessels of tissue samples. The invention improves the stability, quantitative ability and analysis speed of iEESI-MS, and expands the application range of iEESI-MS.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to an internal extraction electrospray ionization source and a mass spectrometry analysis method thereof. Background technique [0002] Mass spectrometry (MS) technology is a universal method with high sensitivity, good specificity and fast response speed among many modern analytical testing technologies. For the vast majority of mass spectrometers, it only takes milliseconds from the generation of analyte ions to the acquisition of ion response signals. The development of soft ionization technology ion sources such as closed structure ESI makes mass spectrometry analysis of macromolecules under normal pressure a Possibly, but most of the mass spectrometry instruments currently equipped in laboratories complete the qualitative and quantitative analysis of an actual sample (such as a specific protein in a tissue sample), and it is necessary to extract and purify the sample tissue ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/10G01N27/62G01N27/626
Inventor 陈焕文周炜刘坤魏益平朱亮徐建军王志豪
Owner EAST CHINA UNIV OF TECH
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