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A kind of eye drop for treating dry eye disease and preparation method thereof

A technology for eye drops and solutions, which is applied to medical preparations containing active ingredients, sensory diseases, pharmaceutical formulations, etc., can solve problems such as undiscovered precedents or literature reports, and achieves elimination of turbid precipitation, accelerated onset time, and reduced the effect of destruction

Active Publication Date: 2018-02-23
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are no previous cases or literature reports about making Guben Mingmu preparation into eye drops

Method used

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  • A kind of eye drop for treating dry eye disease and preparation method thereof
  • A kind of eye drop for treating dry eye disease and preparation method thereof
  • A kind of eye drop for treating dry eye disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0049] Experimental example 1, extraction process experiment

[0050]In this experiment, the method of combining single factor and orthogonal experiment was adopted, and the weighted average coefficient of hydroxysafflower yellow A (abbreviation: HSYA) and total alkaloids was used as the investigation index, and the type of solvent (water, ethanol), solvent concentration (65-95%), dosage (6-10 times), extraction time (1-4h), number of times (2-4 times), temperature control (45-90°C) and other factors to optimize selection, found that the extraction temperature, solvent The dosage and the number of extractions have a great influence on the extraction results, thus screening and determining the best extraction process as follows: adding 90% ethanol to the medicinal materials for 2 extractions, adding 8 times the amount for the first time, extracting for 3 hours, and adding 8 times the amount for the second time, Extracted for 2 hours, the extraction temperature was controlled at...

experiment example 2

[0051] Experimental example 2: Water sinking process experiment

[0052] Weigh 91g of safflower, 91g of myrobalan, and 30.25g of Corydalis serrata, add 90% ethanol to extract twice, add 8 times the volume for the first time, extract for 3 hours, add 8 times the volume for the second time, extract for 2 hours, Filtrate, recover ethanol from the filtrate, and then concentrate to a relative density of 1.25 (measured at 50°C), divide it into 3 parts on average, add 3 times the amount of water to the first part, add 4 times the amount of water to the second part, and add 5 times the amount to the third part Measure water, respectively add to the above-mentioned alcohol-water suspension, stir, let stand for 48 hours, filter, concentrate under reduced pressure, measure the content, and calculate the transfer rate of gallic acid.

[0053] Table 1 Water sinking process analysis table

[0054]

[0055] The results show that adding 3 times the volume of water, the content is slightly...

experiment example 3

[0056] Experimental example 3, bear bile powder processing method experiment

[0057] Bear bile powder is a water-soluble component, and the conventional method and literature method are all to add a certain amount of water to dissolve, and then directly proceed to the next step.

[0058] The present invention adopts the above method to find that the next step of preparation after the bear bile powder is dissolved in water will inevitably lead to turbidity, which cannot be avoided by high-speed centrifugation.

[0059] The present invention finds through experiments that after the bear bile powder is dissolved in water, it is added to the ethanol extract and then precipitated with water, then concentrated to dryness after filtration, dissolved in water, and then added corresponding auxiliary materials to make an eye drop preparation, which can solve the above problems. The specific experiments and results are as follows:

[0060] Mother liquor: the alcohol-extracted water sed...

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Abstract

The invention discloses an eye drop for treating xerophthalmus and a preparation method. The eye drop is prepared from the following raw materials and auxiliary materials in parts by weight: 130-170 parts of an extract containing bear gall powder, 1.5-3.3 parts of borneol, 1-2 parts of a bacteriostatic agent, 6-10 parts of a solubilizer, 40 parts of sodium borate and 10 parts of boric acid. According to the physical and chemical properties of chemical components contained in the medicinal material in the formula, use of volatile oil is removed; the dosage of the borneol and the bear gall powder is adjusted; the borneol and the bear gall powder are added in different manners; muddy opalescence and the like caused by a conventional bear gall powder adding method are reduced; the medicinal composition is ensured; meanwhile, the preparation directly acts on the medication part; the dosage is greatly reduced; the onset time of the medicine is quickened; and the curative effect is improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to an eye drop for treating dry eye and a preparation method thereof. Background technique [0002] Guben Mingmu Granule is an oral preparation, which is made of 6 medicinal materials including safflower, myrobalan, Corydalis cypress, clove, borneol, bear bile powder and sucrose. It has the functions of regulating ulcer and improving eyesight. Blurred vision, conjunctival congestion and dryness, etc. The clinical curative effect is definite. The applicable standard is WS-10485 (ZD-0485)-2002. Jiangni strengthens the spleen; borneol clears the orifices, relieves stagnation, eliminates nebula, improves eyesight; [0003] The patent document "Guben Mingmu Dropping Pills for Treating Eye Diseases and Its Preparation Method" (CN1709419, hereinafter referred to as "Guben Mingmu Dropping Pills Application") discloses Guben Mingmu Dropping Pills, which u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61K9/08A61P27/02A61K35/413A61K33/22A61K31/045
Inventor 牛玉苓张义智李怀平姬涛魏永义彭坤
Owner SHANDONG JINHE DRUG RES DEV
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