Enteric-coated preparation of Panax notoginseng saponins, preparation method and application thereof

A technology of Panax notoginseng saponins and enteric-coated preparations, which is applied in the field of enteric-coated preparations of Panax notoginseng saponins and its preparation, can solve the problems of low dosing rate, sticky pills, etc., and achieve good integrity, short time and fast preparation process continuous effect

Active Publication Date: 2018-04-20
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In the prior art about enteric-coated preparations of Panax notoginseng saponins, most of the process methods are extrusion spheronization method and non-porous coating pan preparation method. During the preparation process, it is easy to cause problems such as sticky pills and low drug application rate, which will affect the content of the pills. Indicators for evaluating drug quality such as release rate

Method used

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  • Enteric-coated preparation of Panax notoginseng saponins, preparation method and application thereof
  • Enteric-coated preparation of Panax notoginseng saponins, preparation method and application thereof
  • Enteric-coated preparation of Panax notoginseng saponins, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1. Prescription for tablet core:

[0066]

Dosage

Panax notoginseng saponins (neither dry nor pure)

40g

Blank core (sucrose)

120g

hypromellose

3.2g

Low-substituted hydroxypropyl cellulose

8g

talcum powder

4.8g

purified water

up to 500ml

[0067] 2. Preparation process

[0068] 1) Preparation of drug solution

[0069] Take 70% of the prescribed amount of purified water, heat it to 50°C, slowly add the prescribed amount of hypromellose and stir continuously until it dissolves, then add low-substituted hypromellose and total saponins of Panax notoginseng in sequence, and continue stirring until the total amount of Panax notoginseng After the saponin is completely dissolved, add talcum powder, keep stirring, and add purified water to make up to the full amount;

[0070] 2) Preparation of the upper drug core: spray the mixed solution in step 1) through the bottom of the fluidized bed, and spray i...

Embodiment 2

[0076] 1. Prescription for tablet core:

[0077]

Dosage

Panax notoginseng saponins (neither dry nor pure)

40g

Blank core (sucrose)

80g

hypromellose

2g

Crospovidone

4g

talcum powder

3.2g

purified water

up to 500ml

[0078] 2. Preparation process

[0079] 1) Preparation of drug solution

[0080] Take 70% of the prescription amount of purified water, heat it to 50°C, slowly add the prescription amount of hypromellose and stir until it dissolves, then add crospovidone and Panax notoginseng saponins in turn, and continue stirring until Panax notoginseng saponins After it is completely dissolved, add talcum powder, keep stirring, and add purified water to make up to the full amount;

[0081] 2) Preparation of the upper drug core: spray the mixed solution in step 1) through the bottom of the fluidized bed, and spray it on the surface of the blank core. The ratio of the total saponins of notoginseng to th...

Embodiment 3

[0087] 1. Prescription for tablet core:

[0088]

Dosage

Panax notoginseng saponins (neither dry nor pure)

40g

[0089] Blank core (sucrose)

40g

hypromellose

2.8g

sodium starch glycolate

6g

talcum powder

4g

purified water

up to 500ml

[0090] 2. Preparation process

[0091] 1) Preparation of drug solution

[0092] Take 70% of the prescribed amount of purified water, heat it to 50°C, slowly add the prescribed amount of hypromellose and stir until it dissolves, then add sodium starch glycolate and total saponins of Panax notoginseng in sequence, and continue stirring until the total saponins of Panax notoginseng are completely dissolved. After dissolving, add talcum powder, keep stirring, and add purified water to make up to the full amount;

[0093]2) Preparation of the upper drug core: spray the mixed solution in step 1) through the bottom of the fluidized bed, and spray it on the surface o...

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Abstract

The invention relates to an enteric-coated preparation of Panax notoginseng saponins and a preparation method thereof. The enteric-coated preparation of Panax notoginseng saponins comprises a pill core, an isolation layer and an enteric layer coated on the pill core in sequence ; The composition of the following parts by weight is included in the core of the upper medicine: 40 parts of Panax notoginseng saponins, 40-120 parts of blank ball cores, 4-8 parts of disintegrants, 2-3.5 parts of binders, 3-5 parts of talcum powder share. The reason why the present invention adds an isolation layer coating between the enteric-coated layer and the pill core is that the surface of the pill core can be smoother, and the coating is more complete and easy to enteric-coated. In addition, the raw material Panax notoginseng saponins have a certain hygroscopicity. In addition, increasing the isolation layer coating can also improve the stability of the pellets. In addition, the present invention adopts the fluidized bed bottom spraying method, and through formula optimization, successfully solves the problem of pellet sticking due to the physical and chemical properties of Panax notoginseng saponins, and obtains a high-quality enteric-coated preparation.

Description

technical field [0001] The invention relates to traditional Chinese medicine preparations, in particular to an enteric-coated preparation of Panax notoginseng saponins, a preparation method and application thereof. Background technique [0002] Panax notoginseng saponins (Notoginseng triterpenes), mainly cures blood circulation and blood stasis dispelling, dredging channels and activating collaterals. It has the effect of inhibiting platelet aggregation and increasing cerebral blood flow, and is used for cerebrovascular sequelae, central retinal vein occlusion, anterior chamber hemorrhage, etc. [0003] The total saponins of Panax notoginseng are extracted from high-quality Panax notoginseng according to the extraction and separation technology. Among them, ginsenoside Rg 1 and Rb 1 Accounting for about 60-70%, it is the main active ingredient that exerts pharmacological effects. [0004] Currently, there are Xuesaitong Tablets, Xuesaitong Capsules, Xuesaitong Granules, ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/62A61K9/58A61K36/258A61P9/00
Inventor方同华王维龙贾文娟周广红韩冰王博于征帆
OwnerHARBIN ZHENBAO PHARMA