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A traditional Chinese medicine compound preparation for inducing immune tolerance and its preparation method and application

A compound preparation, immune tolerance technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of high price, many adverse reactions and complications, avoid interference and inhibit immune rejection. , the research results are reliable

Active Publication Date: 2018-11-27
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Methods for inducing DCregs include pharmaceutical preparations such as immunosuppressants (Hackstein H, ThomsonAW.Dendritic cells:emerging pharmacological targets of immunosuppressivedrugs.Nat Rev Immunol.2004; 4(1):24-34.), physiological media such as matrix Cells, anti-inflammatory cytokines such as IL-10, and genetic engineering techniques such as reducing the expression of costimulatory molecules and promoting the expression of anti-inflammatory cytokines such as TGF-β, etc. (Cai Z, Zhang W, Li M, Yue Y, Yang F, Yu L, Cao X, Wang J. TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+)regulatory T cells. Cell Mol Immunol. 2010; 7(1): 35-43), but there are disadvantages of adverse reactions and complications or expensive

Method used

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  • A traditional Chinese medicine compound preparation for inducing immune tolerance and its preparation method and application
  • A traditional Chinese medicine compound preparation for inducing immune tolerance and its preparation method and application
  • A traditional Chinese medicine compound preparation for inducing immune tolerance and its preparation method and application

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Effect test

Embodiment 1

[0031] A preparation method of a traditional Chinese medicine compound preparation for inducing immune tolerance is carried out according to the following steps:

[0032] Using conventionally processed crude drugs, weigh 2 parts of Bupleurum, 31 parts of Cortex Moutan, 24 parts of Radix Paeoniae Alba, 33 parts of Turmeric Curcuma, and 10 parts of Licorice Root, and grind them into coarse powder, mix them, and soak them in boiling water at 100°C 10-60 minutes, then add 1-8 times of water, extract at 30-100°C for 1-3 hours, and multiple times of water extraction, and finally combine the obtained water extracts for use; Filter with filter paper, centrifuge the filtrate at 1200-12000 rpm for 5-30 minutes, or choose other methods to remove impurities; concentrate by rotary evaporation, freeze-dry, and combine the water extracts.

Embodiment 2

[0034] A preparation method of a traditional Chinese medicine compound preparation for inducing immune tolerance is carried out according to the following steps:

[0035] Using conventionally processed crude drugs (by weight), weigh 30 parts of Bupleurum, 3 parts of Cortex Moutan, 32 parts of Radix Paeoniae Alba, 5 parts of Curcuma, and 30 parts of Licorice, and grind them into coarse powder, mix them, and put them into boiling water at 100 ° C. Soak in water for 10-60 minutes, then add 1-8 times of water, and extract at 30-100°C for 1-3 hours, and multiple times of water extraction, and finally combine the obtained water extracts for use; water extraction The liquid is filtered through filter paper, and the filtrate is centrifuged at 1200-12000 rpm for 5-30 minutes, or other methods can be selected to remove impurities; concentrated by rotary evaporation, freeze-dried, and combined water extracts.

Embodiment 3

[0037] A preparation method of a traditional Chinese medicine compound preparation for inducing immune tolerance is carried out according to the following steps:

[0038] Using conventionally processed crude drugs (by weight), weigh 10 parts of Bupleurum, 22 parts of Cortex Moutan, 11 parts of Radix Paeoniae Alba, 29 parts of Curcuma, and 28 parts of Licorice, and grind them into coarse powder, mix them, and put them into boiling water at 100 ° C. Soak in water for 10-60 minutes, then add 1-8 times of water, and extract at 30-100°C for 1-3 hours, and multiple times of water extraction, and finally combine the obtained water extracts for use; water extraction The liquid is filtered through filter paper, and the filtrate is centrifuged at 1200-12000 rpm for 5-30 minutes, or other methods can be selected to remove impurities; concentrated by rotary evaporation, freeze-dried, and combined water extracts.

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Abstract

The invention discloses a compound Chinese traditional medicine preparation for inducing immune tolerance and preparing method and application thereof. The compound Chinese traditional medicine preparation comprises 2-30 parts of roots of Chinese thorowax, 3-31 parts of moutan bark, 4-32 parts of radix paeoniae alba, 5-33 parts of radix curcumae and 6-35 parts of liquorice. The above components are prepared according to the proportion, to be smashed, soaked with water, decocted, filtered, centrifuged and dried to be made into capsules, oral liquid, tablets and the like. The compound Chinese traditional medicine preparation can induce generation of DC regs of high-expression CD11b and low-expression HLA-DR / CD86 / CD80, the DCregs generated through inducing can effectively inhibit DC-mediated lymphopoiesis and promote secretion of cytokines IL-10; a receptor mice is induced to tolerate the iso-allotransplantation skin; no influence on the motility rate of DC cells and the hepatorenal function of the receptor mice is generated, and the compound Chinese traditional medicine preparation is effective and low-toxic and induces immune tolerance.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a compound traditional Chinese medicine preparation for inducing immune tolerance and its preparation method and application. Background technique [0002] Immune rejection is a bottleneck in tissue and organ transplantation, allergy and autoimmune diseases. At present, in the treatment of immune rejection at home and abroad, the most effective curative effect is immunosuppressant. An ideal immunosuppressant has the characteristics of high efficiency, low toxicity, convenience and economy. However, the immunosuppressants currently used in clinical practice have extensive and strong side effects. The toxicity of liver and kidney increases, and even causes teratogenicity and infertility. For example, the neurotoxic effects of immunosuppressants commonly used in liver transplantation, such as CsA and FK506, have been frequently reported, and both ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P37/06
Inventor 李光陈丹
Owner TIANJIN MEDICAL UNIV
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