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New anti-inflammatory medicine with bone protection function and composed of glucocorticoid and salvia extract

A technology of glucocorticoid and protective effect, which is applied in the field of new anti-inflammatory drugs, and can solve the problems of slow and incomplete recovery from muscle weakness

Inactive Publication Date: 2015-11-18
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Slow and incomplete recovery from muscle weakness

Method used

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  • New anti-inflammatory medicine with bone protection function and composed of glucocorticoid and salvia extract

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Effect test

Embodiment 1

[0021] In order to verify the bone protective effect of the new anti-inflammatory drug composed of glucocorticoid and salvia miltiorrhiza extract, an experiment was designed to use glucocorticoid alone to cause bone damage in rats, and to observe the new anti-inflammatory drug composed of glucocorticoid and salvia miltiorrhiza extract. Observe whether the new anti-inflammatory drug has a protective effect on bone damage caused by glucocorticoids.

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Abstract

The invention relates to new anti-inflammatory medicine with a bone protection function and composed of glucocorticoid and salvia extract. The new medicine has a better curative effect than existing anti-inflammatory action obtained by singly using the glucocorticoid, is free from damage to bones by the glucocorticoid and is new medicine with the bone protection function. The new anti-inflammatory medicine is composed of prednisone acetate and tanshinol, the optimal ratio of the formula is 1:4, and namely the new anti-inflammatory medicine contains 5 mg of prednisone acetate and 20 mg of tanshinol. The new anti-inflammatory medicine comprises the optimal combination of the prednisone acetate, the tanshinol, salvianolic acid B and protocatechualdehyde. The selected salvia extract includes known components with definite chemical structures and stable ingredients and easy to extract, and the compound prescription can be registered as a chemical drug and be approved to produce. The new anti-inflammatory medicine can replace various kinds of glucocorticoid medicine used clinically in China currently.

Description

Technical field [0001] The present invention relates to a group of new anti-inflammatory drugs with bone protection effect composed of glucocorticoids and extracts of salvia miltiorrhiza. The new drugs have stronger anti-inflammatory effects than the current glucocorticoid alone, and there is no glucocorticoid damage to bone It is a new anti-inflammatory drug with bone protection. Background technique [0002] Glucocorticoid drugs are commonly used anti-inflammatory drugs. These drugs are commonly used clinically with prednisone acetate, cortisone, hydrocortisone, prednisone, prednisone, methylprednisolone, and methylprednisolone. Nisone, p-flumethasone, fluprednisolone, triamcinolone, betamethasone, dexamethasone, beclomethasone, etc. Glucocorticoid drugs have important pharmacological effects such as anti-inflammatory, immunosuppressive and anti-shock, but super-physiological doses of glucocorticoid drugs can cause many adverse reactions to the body. This is due to the effect ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K45/00A61P29/00A61P19/08A61K31/58A61K31/56A61K31/57A61K31/573
Inventor 崔燎吴铁陈景锋罗世英许碧莲杨亚军张新乐
Owner GUANGDONG MEDICAL UNIV