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A technology of sevoflurane and inhalants, which is applied in the field of medicine, can solve problems such as limited commercial application value, and achieve the effect of reducing degradation and good stability
Active Publication Date: 2015-12-02
SHANDONG NEWTIME PHARMA
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Problems solved by technology
[0003] A number of methods for the preparation of sevoflurane have been described, many of which have limited commercial application
Method used
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Embodiment 1
[0023] Sevoflurane 375g
[0024] Ethanol 0.375g
[0025] Peppermint oil 0.75g
[0026] Preparation Process:
[0027] Weigh the prescribed amount of peppermint oil, dissolve it in ethanol, add the prescribed amount of sevoflurane, and fill it in a glass bottle.
Embodiment 2
[0029] Sevoflurane 375g
[0030] Ethanol 1.125g
[0031] Peppermint oil 1.5g
[0032] Preparation Process:
[0033] Weigh the prescribed amount of peppermint oil, dissolve it in ethanol, add the prescribed amount of sevoflurane, and fill it in a glass bottle.
Embodiment 3
[0035] Sevoflurane 375g
[0036] Ethanol 0.75g
[0037] Peppermint oil 1.125g
[0038] Preparation Process:
[0039] Weigh the prescribed amount of peppermint oil, dissolve it in ethanol, add the prescribed amount of sevoflurane, and fill it in a glass bottle.
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Abstract
The invention belongs to the technical field of medicine and particularly relates to a sevoflurane inhalant which contains sevoflurane, peppermint oil and ethanol and is prepared through the following method: dissolving peppermint oil in ethanol to form a solution, adding the solution in sevoflurane to form a mixture, and filling the mixture in a glass bottle. Compared with the prior art, the technology is simple, and the stability is excellent.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a sevoflurane inhalation agent. Background technique [0002] The compound sevoflurane (1,1,1,3,3,3-hexafluoroisopropylfluoromethyl ether or hexafluoroisopropylfluoromethyl ether or (CF3)2CHOCH2F) is a widely used inhalational anesthetic, especially Suitable for outpatient surgery. Therefore, a cost-effective method for the preparation of stable sevoflurane is highly desired. [0003] A number of methods for the preparation of sevoflurane have been described, many of which have limited commercial application. U.S. Patent 3,683,092 describes four preparations, three of which start with 1,1,1,3,3,3-hexafluoroisopropylmethyl ether (reaction with potassium fluoride in sulfolane or with bromine trifluoride reaction), one starting with 1,1,1,3,3,3-hexafluoroisopropanol (reaction with formaldehyde and hydrogen fluoride). US Patent 3,897,502 describes the direct fluorina...
Claims
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