Application of tormentic acid in preparation of medicine for treating or preventing Alzheimer disease caused by estrogen lack

A technology for Alzheimer's disease and estrogen deficiency, applied in drug combinations, diseases, pharmaceutical formulations, etc., can solve controversial problems, increase the risk of breast cancer, increase irregular vaginal bleeding, etc., to increase the number, improve Effects on Cognitive Impairment

Active Publication Date: 2015-12-02
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Estrogen replacement therapy has been affirmed, but it is still controversial as a safe long-term drug, such as increasing irregular vaginal bleeding and increasing the risk of breast cancer, etc.

Method used

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  • Application of tormentic acid in preparation of medicine for treating or preventing Alzheimer disease caused by estrogen lack
  • Application of tormentic acid in preparation of medicine for treating or preventing Alzheimer disease caused by estrogen lack

Examples

Experimental program
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Embodiment

[0018] 1 Materials and methods

[0019] 1.1 Modeling and grouping

[0020] Modeling of ovariectomized dementia model mice: C57BL mice, 3 months old and weighing (30±2) g, were selected. The mice were anesthetized intraperitoneally with pentobarbital sodium (0.25mL / 100g) at a mass concentration of 1.5%, and the skin above the pubic bone was disinfected, and the skin above the pubic bone was incised 2 cm along the midline, and the abdominal wall muscle layer was cut and the abdominal cavity was opened. The bilateral pink ovaries were separated and exposed, the bilateral ovaries were ligated and removed (ovariectomy, OVX), the muscles and skin were sutured in turn, and postoperative iodine disinfection was performed. In the sham group, only the ovaries were exposed. The vaginal cell smear was performed on the 3rd day after the operation, and the appearance of epithelial keratinocytes for 7 consecutive days proved that the ovariectomy was successful. The ovariectomy dementi...

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Abstract

The invention discloses application of tormentic acid in preparation of medicine for treating or preventing the Alzheimer disease caused by estrogen lack, and belongs to the technical field of tormentic acid medicine new application. According to the technical scheme, the application is characterized in that the molecular formula of the tormentic acid is C30H48O5, and the structural formula is as shown in specifications; the tormentic acid can improve the cognition impairment of an AD patient and increase the number of in-brain cholinergic neurons and has a neuron protection effect on CNS, wherein the protection effect can be achieved through ERalpha, and the result provides experimental bases for using the tormentic acid as a medicine select for treating menopause women in combination with AD.

Description

technical field [0001] The invention belongs to the technical field of new medical applications of tuccinic acid, and specifically relates to the application of tuccinic acid in the preparation of drugs for treating or preventing Alzheimer's disease caused by estrogen deficiency. Background technique [0002] Alzheimer's disease (Alzheimer's Disease, AD) is a common degenerative disease of the nervous system, manifested as the deposition of senile plaques, progressive learning and memory loss and mental decline. The main component of senile plaques is β-amyloid polypeptide (beta-amyloid, Aβ). Studies have reported that the reduction of estrogen levels in the blood of female patients is closely related to the clinical symptoms of AD. Estrogen not only regulates reproduction and body development, but also reduces excitatory amino acid release, neuroprotection and improves learning and memory. Epidemiology shows that AD is a gender-prone disease, and the incidence rate of eld...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P25/28A61P5/30A61P15/00
Inventor 崔卫刚张应花王松涛孙春莉连辉
Owner XINXIANG MEDICAL UNIV
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