Application of Bacteroides thetaiotaomicron VPI-5482 in preparation of pharmaceuticals for treating or preventing obesity

Abstract

The invention relates to the field of preparation of pharmaceuticals, in particular to application of Bacteroides thetaiotaomicron VPI-5482 in the preparation of pharmaceuticals for treating or preventing obesity. C57 / BL6 male SPF (specific pathogen free) mice of the same litter are randomly divided into a control group and a bacterial filling group. The control group is subjected to aseptic PBS lavage; the bacterial filling group is subjected to Bacteroides thetaiotaomicron VPI-5482 suspension lavage test once a day; feeding with high fat food is performed for 7 weeks of testing, during this period, body weight increase rate of the mice is recorded, and after testing, fat content and the like are detected. Testing shows that the Bacteroides thetaiotaomicron VPI-5482 is very effective in controlling body weight and fat, inguinal subcutaneous fat content is decreased by 35.5%, and near-epididymal fat content is decreased by 23.5%.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to the application of Bacteroidesthetaiotaomicron VPI-5482 in the preparation of medicines for treating or preventing obesity. Background technique [0002] Obesity, as a risk factor for type 2 diabetes, cardiovascular disease and tumors, has become a global social public problem. In the past decade, genome-wide association analysis has discovered more than 100 human obesity susceptibility loci. However, these loci Can only explain a limited number of causes of obesity. Moreover, the current effective treatment methods for obesity are still very limited. Most of the weight-loss drugs approved by the US FDA have been withdrawn from the market due to large side effects or poor effects. It is urgent to develop new weight-loss methods. Another human genome, the gut microbiota genome, is playing an increasingly important role in the development of obesity. Studies have shown that th...

AI Technical Summary

Problems solved by technology

[0002] Obesity, as a risk factor for type 2 diabetes, cardiovascular disease and tumors, has become a global social public problem. In the past decade, genome-wide association analysis has discovered more than 100 human obesity susceptibility loci. However, these loci Explains only a limited portion of obesity pathogenesis

Moreover, the current effective treatment methods for obesity are still very limited. Most of the weight-loss drugs approved by the US FDA have been withdrawn from the market due to large side effects or poor effects. There is an urgent need to develop new weight-loss methods.

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