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External traditional Chinese medicine composition for preventing and treating hand-foot syndromes and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of external use of traditional Chinese medicine composition, can solve problems such as effective treatment of hand-foot syndrome

Active Publication Date: 2015-12-16
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs are not completely effective in the treatment of hand-foot syndrome, the external use of traditional Chinese medicine will inevitably show its irreplaceable advantages in improving the side effects of chemotherapy.

Method used

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  • External traditional Chinese medicine composition for preventing and treating hand-foot syndromes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: preparation of external ointment of the present invention

[0059] Prescription: Sophora flavescens 150g, Speranthum 150g, Angelica 150g, Baixianpi 150g, Angelica dahurica 100g, Radix Paeoniae Rubra 150g

[0060] Preparation method: add 5 times the amount of 95% ethanol to Angelica, Angelica dahurica, and white fresh skin to reflux extract twice, the first time for 1.5 hours, and the second time for 1 hour, combine the alcohol extracts, recover ethanol, concentrate to a clear paste, and wait use. Add red peony root, Sophora flavescens, and Sperantoides decoction twice with 8 times the amount of water, each time for 1.5 hours, and the second time for 1 hour, combine the decoctions, concentrate to a clear paste, and combine with the above-mentioned alcohol extraction clear paste , continue to concentrate to a thick paste. Add matrix and appropriate amount of preservatives into the thick paste, stir, place, fill, and you get it.

Embodiment 2

[0061] Embodiment 2: the typical case of application of the present invention

[0062] Case 1: Chen Moumou, male, 53 years old, from Shijingshan, Beijing

[0063] Condition: The patient suffers from colon cancer with lymph node metastasis, the pathological type is adenocarcinoma, T3N1M0, hand-foot syndrome occurred in the third cycle of taking Xeloda, severe pain with blisters, peeling, ulcers, walking inconvenience, seriously affecting daily life, HFS classification is Grade III. He had a history of type 2 diabetes for 3 years, and his blood sugar was under stable control. Before treatment, his fasting blood sugar was 7.87mmol / L, and he had no diabetic peripheral nerve damage or diabetic foot.

[0064] Treatment: give external application of the ointment obtained in Example 1 of the present invention, twice a day.

[0065] Effect: After 14 days of outpatient follow-up visit, he could walk normally. He complained that he had no obvious discomfort except for numbness and acup...

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Abstract

The invention discloses an external traditional Chinese medicine composition for preventing and treating hand-foot syndromes. The traditional Chinese medicine composition is prepared a method comprising the following steps: taking 12-18 parts by weight of light yellow sophora root, 12-18 parts by weight of tuberculate speranskia herb, 12-18 parts by weight of Chinese angelica, 12-18 parts by weight of densefruit pittany root-bark, 8-12 parts by weight of dahurian angelica root and 12-18 parts by weight of red peony root; performing reflux extraction on the Chinese angelica, the dahurian angelica root and the densefruit pittany root-bark together twice by using ethanol, combining the ethanol extracts, recovering the ethanol, and concentrating to obtain a clear past for later use; decocting the red peony root, the light yellow sophora root and the tuberculate speranskia herb by adding water, combing decoctions, and concentrating to obtain a clear paste; and combining the ethanol extraction clear paste with the water extraction clear paste, continuously concentrating to obtain a thick paste, and adding an appropriate amount of accessories to prepare an external ointment. The external traditional Chinese medicine composition can be used for effectively treating the hand-foot syndromes.

Description

technical field [0001] The invention relates to an external Chinese medicine composition for preventing and treating hand-foot syndrome, a preparation method and application of the composition, and belongs to the field of traditional Chinese medicine. Background technique [0002] Malignant tumors are important diseases that endanger human life and health. Chemotherapy and targeted therapy are the most commonly used clinical treatments. In recent years, biological targeted therapy has made unprecedented progress, and chemotherapy is still an indispensable means of tumor treatment. However, while targeted therapy and chemotherapy have achieved curative effects, the related toxic and side effects have also seriously affected the curative effect of the treatment and life. Quality improved. Among them, hand-foot syndrome is one of the common side effects of chemotherapy and targeted therapy in recent years, because it will directly affect the quality of life of patients, and ev...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61P17/00
Inventor 林洪生李杰
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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