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A supramolecular composite photothermal reagent and its application in photothermal therapy and near-infrared imaging

A compound optical and supramolecular technology, which is applied in the direction of medical preparations containing active ingredients, preparations for in vivo experiments, and pharmaceutical formulations, can solve the problems of multi-functional complexity, poor stability and structural controllability, and achieve High photothermal conversion efficiency, increased therapeutic and imaging effects, and size-controllable effects

Active Publication Date: 2018-10-23
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these carriers generally have disadvantages such as poor stability and structural controllability, and multi-functional complexity.

Method used

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  • A supramolecular composite photothermal reagent and its application in photothermal therapy and near-infrared imaging
  • A supramolecular composite photothermal reagent and its application in photothermal therapy and near-infrared imaging
  • A supramolecular composite photothermal reagent and its application in photothermal therapy and near-infrared imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) prepare the mixed salt solution of magnesium nitrate and aluminum nitrate, the mol ratio of magnesium nitrate and aluminum nitrate is 1:2, and the concentration of magnesium nitrate is 0.1mol / L;

[0034] (2) prepare the mixed solution of sodium dodecylsulfonate and indocyanine green in different proportions, and ultrasonically disperse uniformly; the sum of the moles of sodium dodecylsulfonate and indocyanine green is equal to step (1) The number of moles of soluble trivalent metal salt, the solvent is a mixed solvent of methanol and water, the volume ratio of methanol and water is 1:1, and the molar ratio of sodium dodecylsulfonate to indocyanine green is 1:99 , 2:98, 3:97, 5:95, 10:90, the concentration of indocyanine green is 2mmol / L;

[0035] (3) Under the protection of nitrogen, mix the solution prepared in step (1) and step (2), and then drop the NaOH solution with a concentration of 0.2mol / L until the pH is 8; then control the temperature of the water bath to...

Embodiment 2

[0038] (1) prepare the mixed salt solution of magnesium nitrate and aluminum nitrate, the mol ratio of magnesium nitrate and aluminum nitrate is 1:2, and the concentration of magnesium nitrate is 0.1mol / L;

[0039] (2) prepare the mixed solution of sodium lauryl sulfonate and indocyanine green, ultrasonic evenly disperse; The number of moles of the valent metal salt, the solvent is a mixed solvent of methanol and water, the volume ratio of methanol and water is 1:1, the molar ratio of sodium dodecylsulfonate to indocyanine green is 2:98, indocyanine The concentration of green is 2mmol / L;

[0040] (3) Disperse folic acid into double distilled water, and add a concentration of 0.2mol / L NaOH solution to adjust to the fact that the folic acid is just completely dissolved, the concentration of folic acid is 0.02mol / L, and the molar ratio of folic acid to soluble trivalent metal salt is 1:5;

[0041] (4) Under nitrogen protection, the solution prepared by steps (1), (2) and (3) is...

Embodiment 3

[0044] (1) prepare the mixed salt solution of magnesium nitrate and aluminum nitrate, the mol ratio of magnesium nitrate and aluminum nitrate is 1:3, and the concentration of magnesium nitrate is 0.1mol / L;

[0045] (2) prepare the mixed solution of sodium dodecylsulfonate and indocyanine green in different proportions, and ultrasonically disperse uniformly; the sum of the moles of sodium dodecylsulfonate and indocyanine green is equal to step (1) The number of moles of soluble trivalent metal salt, the solvent is a mixed solvent of methanol and water, the volume ratio of methanol and water is 3:1, and the molar ratio of sodium dodecylsulfonate to indocyanine green is 1:99 , 2:98, 3:97, 5:95, 10:90, the concentration of indocyanine green is 5mmol / L;

[0046] (3) Under the protection of nitrogen, mix the solution prepared in step (1) and step (2), then drop the NaOH solution with a concentration of 0.2mol / L until the pH is 9; then control the temperature of the water bath to 55°...

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Abstract

The invention discloses a supermolecule composite photo-thermal reagent and an application thereof in photo-thermal treatment and near-infrared imaging, and belongs to the technical field of cancer treatment and imaging medicine preparation. Based on the poor self heat stability and water solubility of indocyanine green and other characteristics, Organic photo-thermal reagent indocyanine green and sodium dodecyl sulfate are intercalated between hydrotalcite layers together through a low-temperature coprecipitation synthesis method of a methyl alcohol-water mixed solvent, the composite nano photo-thermal reagent with indocyanine green existing in a high dispersion mode is obtained by adjusting the proportion of indocyanine green to sodium dodecyl sulfate, the reagent is applied to cancer treatment and near-infrared imaging study, and a good effect is achieved. Meanwhile, an identical synthetic method is adopted for intercalating indocyanine green, sodium dodecyl sulfate and targeted molecular folic acid between the hydrotalcite layers together, and the effect of treatment and near-infrared imaging is further enhanced. The supermolecule composite photo-thermal reagent is irradiated by 1.1W / cm<2> near-infrared light of 808 nm for 12 min in the concentration of 8 micrograms / ml, and the survival rate of cancer cells is generally lower than 15%.

Description

technical field [0001] The invention belongs to the technical field of tumor treatment and imaging drug preparation, specifically relates to a supramolecular composite photothermal reagent and a preparation method thereof, and studies its application in tumor photothermal treatment, multifunctional targeting and near-infrared imaging. Background technique [0002] Cancer has become the leading cause of death worldwide and seriously threatens human health. At present, the treatment methods for cancer mainly include surgical resection, radiotherapy, chemotherapy, traditional Chinese medicine and other methods. Although they all have certain therapeutic effects, the treatment has certain risks, and it is easy to relapse and difficult to cure. The side effects are relatively large, or the patient needs to endure huge pain. Photothermal therapy technology is an emerging treatment technology without side effects. This technology uses a class of photothermal reagents with good ph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K41/00A61K47/02A61P35/00
Inventor 梁瑞政李春阳卫敏
Owner BEIJING UNIV OF CHEM TECH
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