Application of menin factor

A factor-response technology, applied in the application field of tumor suppressor Menin, can solve the problem that the role of pancreatic cancer has not been studied.
CN105219859BActive Publication Date: 2019-10-25SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2019-10-25

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Abstract

The invention provides an application of a tumor inhibiting factor menin to diagnosis and treatment of pancreatic cancer. The mechanism that the menin factor inhibits growth of pancreatic cancer cells through overexpression is elaborated; on one hand, the menin factor inhibits growth of the pancreatic cancer cells by inhibiting expression of up-regulated genes p18, p27, HOXA9, HDAC5 and CBX4 and expression of down-regulated genes CDK2, CDK4, ESM1, IGFBP7 and GAS1; on the other hand, the menin factor is competitively combined with Dnmt1 to reduce the DNA methylation level of p18 / p27 promoters and promotes transcription of p18 / p27 genes to inhibit growth of the pancreatic cancer cells, and a new way is provided for treating the pancreatic cancer.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to the application of a tumor suppressor Menin. Background technique

[0002] Pancreatic cancer is currently known as a fatal cancer that seriously affects human health. Almost all patients with pancreatic cancer will face cancer cell metastasis, and finally die due to the uncontrollable growth of cancer cells. Therefore, understanding the pathogenesis of pancreatic cancer as well as the mechanism of development and prognosis is very important for the diagnosis, prevention and treatment of this disease.

[0003] Similar to other malignant tumor diseases, pancreatic cancer is mainly caused by the accumulation of acquired mutations in genes, such as mutations in oncogenes, tumor suppressor genes, and genome maintenance genes. The mutation rates of individual tumor suppressor genes K-ras, p16, TP53, MADH4 and BRCA2 in pancreatic cancer were 85%, 82%, 76%, 53% and 10%, respect...

Claims

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