Protein chip fully-automated high-throughput analysis method and protein chip fully-automated high-throughput analysis apparatus

A protein chip and analysis device technology, which is applied in the field of fully automated high-throughput analysis of protein chips, can solve problems such as deviations in test results, and achieve the effects of saving reagents, increasing reliability, and accurate test results

Active Publication Date: 2016-01-27
RAYBIOTECH INC GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the standard, quality control and samples are not tested in parallel at the same time, the test results have a large deviation when using the standard curve of the previous batch to calculate the samples of the next batch.

Method used

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  • Protein chip fully-automated high-throughput analysis method and protein chip fully-automated high-throughput analysis apparatus
  • Protein chip fully-automated high-throughput analysis method and protein chip fully-automated high-throughput analysis apparatus
  • Protein chip fully-automated high-throughput analysis method and protein chip fully-automated high-throughput analysis apparatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] like Figure 1~2 As shown, the present invention provides a protein chip analysis device, including a control host, a display electrically connected to the control host, and a fully automatic protein chip workstation. The table of the fully automatic protein chip workstation is provided with: sample processing system, reagent processing system, plate washing system and signal acquisition system; the top of the table of the fully automatic protein chip workstation is provided with a free mechanical arm and a liquid addition system. The sample processing system, reagent processing system, plate washing system, signal acquisition system, free mechanical arm and liquid addition system are electrically connected to the control host.

[0040] Wherein, the sample processing system includes a tip carrier 1 for placing a tip tray 2 , a sample carrier 5 for placing a sample, a reagent carrier 6 for placing reagents required for an enzyme-linked reaction, and a barcode scanner 3 ....

Embodiment 2

[0062] The following is the specific implementation of using the protein chip automatic analysis device described in Example 1 to operate the humanTh1 / Th2 quantitative chip of Ruiboao. First, the corresponding reagent components in the reagent kit are added to the corresponding reagent carrier 6 in the analysis device, and the barcode scanner 3 automatically scans the barcodes of the reagents. The HumanTh1 / Th2 QuantibodyArray protein chip is placed on the incubation platform 9 in the reagent processing system, the serum sample is placed on the sample carrier 5 of the analysis device, and the barcode scanner 3 automatically scans the barcode of the sample. Click the start experiment button on the operation interface. The monitoring experiment operation starts immediately. The whole experimental process does not require human intervention. The test results are issued in the form of a test report.

[0063] At the beginning of the experiment, the control host automatically load...

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PUM

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Abstract

The present invention discloses a protein chip fully-automated high-throughput analysis apparatus, which comprises a control host machine, a display electrically connected to the control host machine, and a fully-automatic protein chip workstation, wherein the table surface of the fully-automatic protein chip workstation is provided with a sample treatment, a reagent treatment system, a plate washing system and a signal acquisition system, a free mechanical arm and a liquid adding system are added above the table surface of the work station, and the sample treatment system comprises a suction head support frame, a sample support frame, a reagent support frame and a barcode scanner. With the protein chip analysis apparatus of the present invention, the simultaneous detection on the multiple samples, the standard substance and the quality control substance can be achieved, the calculation on the concentration of the current batch of the samples through the current batch of the standard substance and the quality control substance is achieved, and the detection result is accurate and stable; and the multiple samples share the one standard substance or quality control substance so as to achieve the agent saving effect.

Description

technical field [0001] The invention relates to the technical field of protein chip detection, and specifically discloses a protein chip fully automatic high-throughput analysis method and device. Background technique [0002] Protein and antibody chip is a high-density immobilized protein or antibody on the surface of solid-phase substrate (silicon wafer, glass, nitrocellulose membrane), which has the function of high-throughput detection of multiple indicators such as antigen or antibody in biological samples . Compared with the traditional single-index detection ELISA method, the protein chip has the advantages of large detection throughput, small sample requirements, and high detection efficiency (can detect hundreds of indicators in one small hole at the same time), so it is especially suitable for clinical use. Simultaneous detection of multiple indicators, for example, simultaneous detection of multiple tumor markers. However, due to the complicated operation proces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00G01N33/68
Inventor 黄若磐毛应清张卓
Owner RAYBIOTECH INC GUANGZHOU
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