A kind of porcine pseudorabies live vaccine-mycoplasma swine pneumonia live vaccine combination and its application

A technology for Mycoplasma suis pneumonia and Porcine pseudorabies, which can be used in drug combinations, antiviral agents, antibody medical components, etc., and can solve problems such as titer decline

Active Publication Date: 2019-02-26
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a combination of porcine pseudorabies live vaccine-mycoplasma swine pneumonia live vaccine, to solve the problem of continuous stress of the two vaccines respectively immunizing the vaccinated animals, and to avoid the long-term contact of the two antigen components of the joint vaccine. reduce the risk of falling prices, while simplifying the immunization procedures

Method used

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  • A kind of porcine pseudorabies live vaccine-mycoplasma swine pneumonia live vaccine combination and its application
  • A kind of porcine pseudorabies live vaccine-mycoplasma swine pneumonia live vaccine combination and its application
  • A kind of porcine pseudorabies live vaccine-mycoplasma swine pneumonia live vaccine combination and its application

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Embodiment Construction

[0013] The combination of the present invention comprises porcine pseudorabies live vaccine, swine mycoplasma pneumonia live vaccine and vaccine diluent. in:

[0014] 1. Porcine pseudorabies live vaccine is made by inoculating chicken embryo fibroblasts with an attenuated strain of porcine pseudorabies virus (Bartha-K61 strain), harvesting the cell culture, adding a suitable freeze-drying protective agent, and making it through freeze-vacuum drying.

[0015] 2. The live vaccine of Mycoplasma suis pneumonia is prepared by inoculating a suitable culture medium with Mycoplasma hyopneumoniae (RM48 strain), harvesting the culture, adding a suitable freeze-drying protective agent, and making it through freeze-vacuum drying.

[0016] 3. The diluent, the main component is the diluent of PBS or normal saline.

[0017] 4. Dilute the porcine pseudorabies live vaccine with PBS diluent or normal saline as the main component, dilute to contain 1 portion of porcine pseudorabies live vaccine...

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Abstract

The invention relates to a pig pseudorabies live vaccine-pig mycoplasma pneumonia live vaccine composition and the application thereof. When the vaccine composition is applied to immune animals, two vaccines can be obtained to achieve different immune effects, continuous stress on inoculated animals caused by independent immunity can be avoided, immune procedures are simplified, and immunization workload is reduced for a pig farm.

Description

technical field [0001] The invention relates to a porcine pseudorabies-mycoplasma swine pneumonia live vaccine combination, which belongs to the field of veterinary biological products. Background technique [0002] Porcine pseudorabies (Pseudorabies, PR) is a highly contagious disease caused by pseudorabies virus (PRV), which can cause reproductive disorders in breeding pigs, piglet respiratory syndrome, neurological symptoms, diarrhea, and growth and development. symptoms, and PRV is also one of the important primary pathogens causing porcine respiratory disease syndrome (SARAH G, HERMAN W F, LENNERT S, et al. A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa. Vet Res, 2011, 42(4):79-83.) (LAURENCE F, CLAIRE RG, MARIELLE C, et al. Transcriptomic analysis of the dialogue between Pseudorabies virus and porcine epithelial cells during infection. BMC Genomics, 2008, 9:51-56.). T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/245A61K39/02A61P31/22A61P11/00A61P31/04
Inventor 王蕾魏联果周忠涛孙旭燕李营张丹董海曼徐龙涛张广杨健
Owner QILU ANIMAL HEALTH PROD
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