Application of SNF5 in aspect of liver cancer inhibition
A technology for inhibiting liver cancer, which is applied in the application field of SNF5 in inhibiting liver cancer, can solve the problem that the mechanism of action is not very clear, and achieve the effect of improving sensitivity
Inactive Publication Date: 2016-04-06
中国医科大学
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[0005] SNF5 contains two Rpt domains related to protein-protein binding and participates in the process of targeting the target promoter of the SWI / SNF complex, but its specific mechanism of action is not very clear now
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[0021] The present invention will be described in detail below in conjunction with the accompanying drawings.
[0022] Such as figure 1 As indicated, the SNF5 expression plasmid was constructed.
[0023] S1. Liver cancer cell lines HCCLM3 and Hep3B were infected with an shRNA lentiviral vector targeting SNF5, and a liver cancer cell line and a control cell line that stably silenced SNF5 were established.
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The invention provides application of SNF5 in the aspect of liver cancer inhibition. The application comprises the application in the following aspects: the application of the SNF5 as a target spot in early discovery and treatment of liver cancer; the SNF5 having a function of being capable of inhibiting the growth, proliferation and migration of liver cancer cells; the SNF5 inhibiting the expression of CCND1 and TGFbeta1 and promoting expression of P21; the SNF5 being capable of inhibiting the migration and invasion of liver cancer cells HCCLM3 and Hep3B; the SNF5 being capable of improving the sensitivity of the liver cancer cells to sorafenib. The application of the SNF5 has the beneficial effect that a new thought and a new target spot are provided for treating liver cancer.
Description
technical field [0001] The invention belongs to the technical field of biological genes, and in particular relates to the application of SNF5 in inhibiting liver cancer. Background technique [0002] Hepatocellular carcinoma (Hepatocellular carcinoma, HCC) is a common tumor worldwide and a malignant tumor with poor prognosis. The five-year survival rate is only about 10%, and it causes 250,000-1,000,000 deaths worldwide every year. The incidence of HCC has significant gender differences, and the ratio of male to female is 6-8:1, suggesting that sex hormone receptors play a role in the development of HCC. [0003] The switch / sucrose nonfermentable (SWI / SNF) complex is a widely studied chromatin remodeling complex, which was first used to regulate mating type switching (mating type switching, SWI) and A gene that affects sucrosenon-fermenting (SNF) was discovered. The complex is highly conserved in evolution and widely expressed in eukaryotes, mainly composed of proteins enc...
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IPC IPC(8): C07K14/47A61P35/00
CPCC07K14/4702
Inventor 赵越孙洪邈王春玉邹仁龙王胜利孙士莹林琳闻涛孙戈孙宁丛日娇曾凯刘伟杨磊
Owner 中国医科大学