A kind of preparation supercritical fluid chromatograph with multi-port valve and method for preparation separation and purification

A supercritical fluid, multi-port valve technology, applied in material separation, instruments, scientific instruments, etc., can solve the problems of increased separation cost and unsatisfactory product purity, and achieve improved separation effect, low cost and good separation effect.

Inactive Publication Date: 2017-07-18
LIAOCHENG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when performing sample separation, it is difficult to obtain the ideal separation effect for complex samples, and the purity of the product obtained by one-dimensional separation is sometimes not ideal.
In addition, when the sample is separated, a large amount of eluent needs to be used, which also increases the cost of separation

Method used

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  • A kind of preparation supercritical fluid chromatograph with multi-port valve and method for preparation separation and purification
  • A kind of preparation supercritical fluid chromatograph with multi-port valve and method for preparation separation and purification

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Embodiment Construction

[0027] The present invention will be described in detail below in conjunction with the embodiments and drawings, but the scope of protection is not limited thereto.

[0028] Examples such as figure 1 As shown, a preparative supercritical fluid chromatograph with a multi-port valve is composed of a pre-separation system and a main separation system. The pre-separation system consists of delivery system 1, sample injection system Cs, pre-separation column C1, detector D1, multi-way valve V1, trapping column system C2, multi-way valve V2, detector D2, and back pressure valve B1; the main separation The system consists of delivery system 2, multi-way valve V3, trapping column system C2, multi-way valve V4, multi-way valve V5, separation column system C3, multi-way valve V6, detector D3, multi-way valve V7, component collector S, composed of back pressure valve B2. Delivery system 1 is composed of supercritical carbon dioxide delivery pump P1 and improver 1 delivery pump P2, and ...

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Abstract

The invention provides a preparation supercritical fluid chromatographic instrument with a multi-way valve and a separation and purification method of the preparation supercritical fluid chromatographic instrument. Complicated mixed components to be separated are efficiently separated through on / off switching of the multi-way valve by adopting a separation mode including pre-separation performed by a pre-separation column, capturing performed by a plurality of capturing columns and separation performed by a plurality of main separation columns; the separated components are collected in a collector through the on / off switching of the valve, and a mobile phase without the separated components is returned back to a system for cyclic utilization. The supercritical fluid chromatographic instrument provided by the invention is simple in design, good in separation effect and extremely high in practicability, and is applicable to separation and purification of various types of complicated mixtures.

Description

technical field [0001] The invention belongs to the technical field of instrument and equipment manufacturing, in particular to a preparative supercritical fluid chromatograph with a multi-way valve and a method for preparative separation and purification. Background technique [0002] Supercritical fluid chromatography (SFC) using supercritical fluid as mobile phase is a chromatographic process that relies on the solvating ability of the mobile phase for separation and analysis. It is a new technology developed and perfected in the 1980s. [0003] Supercritical fluid is a state of matter above the critical pressure and critical temperature. It has some properties of gas and liquid, with low viscosity of gas, high density of liquid and high density between gas and liquid. Diffusion coefficient and other characteristics, SFC is a supplement to GC and LC, SFC can solve the problem of gas-liquid chromatography analysis, it can analyze non-volatile samples that are difficult to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 柳仁民孙爱玲
Owner LIAOCHENG UNIV
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