Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application method for melatonin dropping pill

A technology of melatonin and dripping pills, which is applied in the field of new pharmaceutical preparations, can solve the problems of first-pass effect, melatonin can not quickly enter the brain and take effect, and achieve the effect of shortening the drug dose and improving sleep

Inactive Publication Date: 2016-06-15
刘佳迪
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, melatonin preparations currently produced and used in China, such as oral liquids, capsules, etc., are digested and metabolized first after being swallowed and administered, which has a first-pass effect, and melatonin cannot all enter the brain quickly and take effect
Although melatonin lozenges can avoid the first-pass effect, there is no domestic production of foreign products

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application method for melatonin dropping pill
  • Preparation method and application method for melatonin dropping pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] Taking melatonin drop pills with a weight of 30 mg and each pill containing 1.0 mg of melatonin as an example, a preparation method and administration method of melatonin drop pills are given:

[0010] prescription:

[0011] Melatonin 1.0g

[0012] PEG4006.0g

[0013] PEG600023.0 g

[0014] Total 30.0 grams

[0015] Preparation method: take 1.0 g of melatonin fine powder, add 6.0 g of PEG4000, stir well to dissolve; take another 23.0 g of PEG60000, heat it on a water bath to melt, add it to the PEG400 solution of melatonin fine powder, stir , mix well. Put this mixture as a raw material in a dropping pill machine, keep the temperature at 65±2°C, and drop 30 mg per pill into liquid paraffin in an ice-water bath to condense. After taking it out, dry the liquid paraffin on the surface of the dropping pills with filter paper at a room temperature of about 25°C to obtain the product.

[0016] The obtained melatonin drop pills should be stored at room temperature in a s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Directed at the current situation of no buccal melatonin preparation in China, the invention discloses preparation of a buccal melatonin dropping pill. The prepared dropping pill weighs 0.01 to 0.09 g (i.e., 10 to 90 mg) and contains 1.0 to 6.0 mg of melatonin. The application method for melatonin dropping pill is to keep one or more melatonin dropping pills in the mouth in 10 to 60 min before sleeping and allow the pills to naturally thaw before sleeping. According to the invention, the first pass effect of oral administration of a melatonin oral liquid or melatonin capsule is prevented, and sleep can be rapidly improved by using a small dosage of the melatonin dropping pill. The properties, dissolving and dispersion limits, stability and other indexes of the melatonin dropping pill prepared in the invention accord with related requirements for dropping pills prescribed in Chinese Pharmacopeia.

Description

technical field [0001] The invention relates to a new pharmaceutical preparation. Background technique [0002] Melatonin (melatonin, melatonin) has the effect of improving sleep, and the action site is in the brain. However, melatonin preparations currently produced and used in China, such as oral liquids and capsules, are digested and metabolized first after being swallowed and administered, which has a first-pass effect, and melatonin cannot all enter the brain quickly and take effect. Although melatonin lozenges can avoid the first-pass effect, there is no domestic production of foreign products. In my country, the drop pill preparation technology is mature, and its basic requirements refer to the drop pill under the second appendix IH pill item of "Pharmacopoeia of the People's Republic of China" in 2010. Dropping pills can be swallowed and administered, and the drug can be absorbed through the oral mucosa to avoid the first-pass effect. For example, Compound Danshen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K31/4045A61K47/34A61P25/20
Inventor 刘佳迪
Owner 刘佳迪
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com