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Low-frequency magnetic field generator for cell experiment researches

A magnetic field generator and experimental research technology, applied in the direction of instruments, scientific instruments, measuring devices, etc., to achieve good application prospects, low cost, and easy to achieve effects

Inactive Publication Date: 2016-06-15
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It is of great significance to record the electrophysiological properties of cells while being magnetically stimulated. However, the low-frequency magnetic field generators currently used for cell experimental research have not yet achieved stimulation while recording the electrophysiological properties of cells.

Method used

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  • Low-frequency magnetic field generator for cell experiment researches
  • Low-frequency magnetic field generator for cell experiment researches

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The user realizes parameter setting through the human-computer interaction module (3).

[0026] The MCU (2) controls the signal generation module (4) to output the corresponding signal according to the set parameters, and then sends it to the power amplifier module (5), which outputs a large current to drive the coil (7), and the power supply module (6) provides power for each part Module power supply.

[0027] Place the cell (9) in the perfusion tank (11), place the coil (7) at the concentric position with the cell (9) through the movable plastic arm (10), move the patch clamp electrode (12) stably to the measured The cells (9) are sealed.

[0028] Start the magnetic field generator (1) to generate the desired magnetic field, and move the coil (7) sideways to maximize the magnetic field acting on the cells.

[0029] At the same time, electrophysiological characteristics are recorded through the patch clamp electrodes (12).

[0030] Complete the entire stimulation pr...

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Abstract

The invention relates to a low-frequency magnetic field generator used for cell experiment research. Its basic components include: a magnetic field generator part, a coil part and a patch clamp recording part. The magnetic field generator part mainly includes: MCU, human-computer interaction module, Signal generation module, power amplification module, power supply module, human-computer interaction module to realize the input and display of user commands, MCU as the core to realize the generation of signals and the control of various parameters, etc., the coil is fixed on the patch clamp microscope through a movable plastic arm On the mirror arm, the user selects the waveform, intensity and duty cycle of the signal through the human-computer interaction part, and the single-chip microcomputer controls the signal generation part to output the corresponding signal according to the selected parameters, and then sends it to the power amplifier circuit to output a large current to drive the diaphragm The coil on the clamp generates the magnetic field expected by the user, stimulates and records the electrophysiological properties of the cells through the patch clamp electrodes.

Description

technical field [0001] The invention relates to a low-frequency magnetic field generator used for cell experiment research, in particular to a device capable of recording cell electrophysiological characteristics with patch clamps while being stimulated by a low-frequency magnetic field. Background technique [0002] The impact of magnetic fields on human health has attracted widespread attention at home and abroad. Studies have shown that the increase in the incidence of childhood leukemia is related to low-frequency magnetic fields. Modern epidemiology also shows that long-term exposure to low-frequency magnetic fields will affect the psychological state of professional groups have a noticeable impact. [0003] At the same time, the magnetic field also has another aspect of helping to treat Parkinson's disease, Alzheimer's disease and other mental diseases. Therefore, the research on the effect of magnetic field on the electrophysiological characteristics of cells is of gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/483
CPCG01N33/483
Inventor 郑羽东磊刘东远王慧泉高杨窦珺嵘
Owner TIANJIN POLYTECHNIC UNIV
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