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A method for treating haemorrhage, shock and brain injury

A technology for blood pressure and hypotension, applied in the field of treatment of hemorrhage, shock and brain injury, which can solve the problems of blood-brain barrier function recovery and non-existence of global treatment strategies

Inactive Publication Date: 2016-06-22
低温药理KF有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After 40% blood loss in beagle dogs, resuscitation with hypertonic (3%) saline was associated with lower intracranial pressure values ​​and less cerebral edema than isotonic saline or colloid resuscitation, but blood-brain barrier function was not Recovered without hypertonic saline resuscitation
[0005] Currently, no effective global treatment strategy exists for hypotensive support for noncompressible bleeding in soldiers or civilians with or without suspected TBI

Method used

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  • A method for treating haemorrhage, shock and brain injury
  • A method for treating haemorrhage, shock and brain injury
  • A method for treating haemorrhage, shock and brain injury

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Embodiment Construction

[0028] The present invention relates to methods of increasing blood pressure to optimal levels in subjects experiencing life-threatening hypotension or shock. The invention also relates to compositions for use in these methods and pharmaceutical formulations suitable for such treatments.

[0029]In one aspect, the invention provides a method of increasing blood pressure in a subject experiencing life-threatening hypotension or shock, the method comprising administering (i) a compound selected from at least one of : Potassium channel openers, potassium channel agonists and adenosine receptor agonists; and (ii) antiarrhythmic agents or local anesthetics. Preferably, the method further comprises administering an elevated source of magnesium ions. The method can also include administering an anti-inflammatory agent and / or a metabolic fuel.

[0030] It should be understood that the components of the composition may be administered simultaneously, sequentially or separately depend...

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Abstract

The invention relates to a composition and method for increasing blood pressure, including a low pain or analgesic state or hypotensive anaesthesia in a subject that has suffered a life threatening hypotension or shock or reducing hypofusion in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; and (ii) an antiarrhythmic agent or a local anaesthetic.

Description

technical field [0001] The present invention relates to a method of increasing blood pressure to optimal levels in subjects who have experienced life-threatening hypotension or shock. The invention also relates to a method of increasing the blood pressure of a subject in shock, especially after circulatory collapse or infection or burn shock or disease. The methods of the invention relate to protecting the brain of a subject after injury. The invention also relates to a method for reducing the deleterious effects of hypoperfusion throughout the body prior to further resuscitation or definitive care. The present invention also includes a method for attenuating the deleterious effects of brain injury prior to definitive care without blood loss. This application claims priority to Australian Provisional Patent Application Nos. 2013902656, 2013902657, 2013902658, 2013902659 and 2013903644, the entire disclosures of which are incorporated herein by this cross-reference. Backgro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61K31/167A61K33/06A61P7/08A61P9/06A61P23/02
CPCA61K31/167A61K31/519A61K45/06A61K31/7004A61K9/0019A61K47/26A61K31/7076A61K33/06A61P17/02A61P23/00A61P23/02A61P25/04A61P25/20A61P29/00A61P41/00A61P7/02A61P7/08A61P9/06A61P9/10A61K2300/00A61K31/194A61K9/08A61K31/05A61K31/19
Inventor 杰弗里·多布森
Owner 低温药理KF有限公司
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