Novel stimulating electrode based in-vitro brain slice electrical signal recording device

A technique of stimulating electrodes and isolated brain slices, which can be applied to measuring devices, diagnostic records/measurements, and preservation of human or animal bodies. It can solve the problems of no efficient stimulating microelectrodes, automatic temperature control, and inconvenient use Achieve excellent electrical conductivity and biocompatibility, improve measurement accuracy, and good shock absorption effect

CN105850984AActive Publication Date: 2016-08-17THE THIRD AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
4 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2016-08-17

Smart Images

  • Figure 1
    Figure 1
Patent Text Reader

Abstract

The invention discloses a novel stimulating electrode based in-vitro brain slice electrical signal recording device which comprises a brain slice recording slot, a brain slice storage slot, a gas supply device, a perfusing drug-delivery device, a temperature control device, an electrode fixing and operating device, a neural network signal recording device and a dissecting microscope. Two microelectrodes are fixed to the electrode fixing and operating device and are inserted into a feeding groove from a top cover of the brain slice recording slot, the other end of each microelectrode is connected with the neural network signal recording device through a lead, the two microelectrodes are a stimulating microelectrode and a recording microelectrode respectively, and the stimulating microelectrode is an epoxy resin / graphene / nano-copper composite material electrode. The novel stimulating electrode based in-vitro brain slice electrical signal recording device effectively overcomes the defect that an old in-vitro brain slice recording device cannot automatically control the temperature, is provided with a smaller feeding groove, is inconvenient to use and makes records inaccurate and does not efficiently stimulate microelectrodes due to shake caused by various situations.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of local preservation and testing of human or animal tissues, and in particular relates to an electrical signal recording device for isolated brain slices based on a novel stimulating electrode. Background technique

[0002] Gamma neural oscillation is a 30-80Hz synchronous signal that exists in many areas of the human and animal brains. Studying neural oscillations can understand the neural characteristics of animal and human cognition, learning, memory, excitement and arousal, and is a hotspot in medical and psychological research. Currently, known isolated neural network oscillation techniques include brain slice recording devices, brain slice recording tanks, gas supply devices, perfusion drug delivery devices, lighting and temperature control devices, electrode fixation and manipulation devices, neural network signal recording devices, shielding And grounding device and system shockproof device. After...

Examples

Embodiment Construction

[0016] In order to better understand the above-mentioned technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. An isolated brain slice electrical signal recording device based on a novel stimulating electrode, including a brain slice recording tank 1, a brain slice storage tank, a gas supply device, a perfusion drug delivery device, a temperature control device, an electrode fixing and operating device, and a neural network signal Recording device and dissecting microscope, described brain slice recording groove 1 is the container of cuboid shape, has mixed oxygen input port 2 on the container side wall, is provided with in the container and nurtures groove 3, and the projection shape of this nurtures groove 3 is two The relatively short sides are arc-shaped, and the two relatively long sides are straight axisymmetric figures. The arc-shaped part on the front s...