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Oral dissolving film preparation containing bulleyaconitine A and preparation technology of oral dissolving film preparation

A technology of aconitin and disperse film, which is applied in the direction of non-active ingredient medical preparations, active ingredient-containing medical preparations, anti-inflammatory agents, etc., and can solve the problem of being unable to cover up numbness

Active Publication Date: 2016-10-12
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We use sweeteners, menthol, etc. for flavoring, and it is almost impossible to hide the numbness

Method used

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  • Oral dissolving film preparation containing bulleyaconitine A and preparation technology of oral dissolving film preparation
  • Oral dissolving film preparation containing bulleyaconitine A and preparation technology of oral dissolving film preparation
  • Oral dissolving film preparation containing bulleyaconitine A and preparation technology of oral dissolving film preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of aconitin complex:

[0029] Measure about 80ml of ethanol and pour it into a beaker, then accurately weigh aconitin (A) and polypropionic acid resin II (B) according to the amount added in Table 1, and finally add them slowly to ethanol, stir until dissolved, Place in a drying oven to dry. After drying, take it out and crush it through a 120-mesh sieve for subsequent use.

[0030] Prescription of grass-aconitin dispersed film:

[0031]

[0032] Process:

[0033] Slowly add the above-mentioned amount of polyvinyl alcohol-polyethylene glycol copolymer into water, stir and disperse fully to obtain a glue solution, then add the above-mentioned amount of glycerin and aconitin complex, stir well and let it stand overnight to remove air bubbles. The glue solution was applied to a glass plate and then dried.

[0034] It is easy to apply, and a uniform and flexible film can be obtained after cutting. The content of each film is 0.4 mg. The numbness evaluatio...

Embodiment 2

[0039]

[0040] Process:

[0041] First slowly add the above amount of hypromellose into water, fully stir and disperse to obtain a glue solution, then add the above amount of polyethylene glycol 400 and aconitin complex, stir evenly, let it stand overnight to remove air bubbles, and The glue solution was applied to a glass plate, dried and then cut.

[0042] Easy and uniform coating; cutting to obtain a flexible translucent film with good mechanical strength and almost no numbness.

Embodiment 3

[0044]

[0045] Process:

[0046] First slowly add the above amount of hypromellose into water, stir and disperse fully to obtain a glue solution, then add the above amount of polyethylene glycol 400, and finally add low-substituted cellulose sodium and aconitin complex, and stir evenly After standing overnight to remove air bubbles, the glue solution was applied to a glass plate, dried and then cut.

[0047] After coating and cutting, a flexible translucent film is obtained, with good mechanical strength and almost no numbness.

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PUM

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Abstract

The invention belongs to the field of medicinal preparations, and discloses an oral dissolving film preparation containing bulleyaconitine A and a preparation technology of the oral dissolving film preparation. The dissolving film contains bulleyaconitine A, polyacrylic resin II, a film forming substrate, a sweetening agent, a saliva irritant and essence. With the dissolving film, the tingling sensation and bitter taste of bulleyaconitine A can be well masked, and the preparation method is simple and feasible.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an orodispersible film preparation of aconitin and a preparation process thereof. Background technique [0002] Pain is a disease. In 1998, the WHO survey showed that the incidence of pain was 22%; in 2004, the EU survey showed that the incidence of moderate to severe pain was 18%; 80%; In the 21st century, tumors have become the number one killer of human beings, and the incidence of cancer pain is 25% in the middle stage after diagnosis, and as high as 70-90% in the late stage. At present, pain has become a major disease that seriously affects the quality of human life. [0003] At present, the principle of pain treatment in the world is to suppress noxious stimuli to achieve maximum analgesia, minimum adverse reactions, maximum function and the highest quality of life. However, a survey in 2005 showed that the proportion of uncontrolled pain was still a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K31/439A61P29/00A61P25/04
CPCA61K9/006A61K9/7007A61K31/439A61K47/32
Inventor 佘振南侯代松丁江生王京昆张天财
Owner YUNNAN INST OF MATERIA MEDICA
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