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Application of strictosamide to preparation of anti-inflammatory drugs

A technology of isovinposide lactam and anti-inflammatory drug, which is applied in the application field of isovinposide lactam in the preparation of anti-inflammatory drug, and can solve the problem that there is no isovinoside lactam yet.

Inactive Publication Date: 2016-12-07
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In the current patent report, vinblastam mainly has the following applications: (1) application of vinblastam in the preparation of anti-pigmentation drugs for skin (CN103585167A), (2) preparation of vinblastam (CN102600197A), (CN102600197A), (CN102600197A), (3) the use of a combination preparation containing vinca lactam and other components in the preparation of heat-clearing, detoxifying, swelling and pain-relieving drugs (CN102600269A); Report on the application of anthocyanin lactam in anti-inflammation

Method used

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  • Application of strictosamide to preparation of anti-inflammatory drugs
  • Application of strictosamide to preparation of anti-inflammatory drugs
  • Application of strictosamide to preparation of anti-inflammatory drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] Example: Vinblastam has a good inhibitory effect on inflammation in RAW 264.7 cells stimulated by LPS.

[0019] (1) Cell culture

[0020] Mouse RAW 264.7 macrophages were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences. at 37°C, 5% CO 2 Under the condition, cultured with DMEM incomplete medium containing 10% HyClone fetal bovine serum, 100U / mL penicillin and 100mg / mL streptomycin, digested and passaged with 0.5% trypsin. All operations are performed aseptically.

[0021] (2) Cell Viability Experiment

[0022] RAW 264.7 cells were seeded in 96-well plates (4×10 6 cells / mL), each group had six replicate wells, and each well contained 200 μL of incomplete high-glucose DMEM medium. After the cells adhered to the wall, the cells were washed once with PBS. The control group was added with incomplete high-glucose medium, the induction group was added with incomplete high-glucose medium containing 1 μg / mL LPS, and the administration group was added...

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Abstract

The invention belongs to the technical field of medicines and in particular discloses application of strictosamide to preparation of anti-inflammatory drugs. The strictosamide is extracted and separated from nauclea officinalis medicinal materials. The strictosamide can achieve the effects of obviously inhibiting growth of inflammatory factors IL-1beta and TNF-alpha in LPS-stimulated RAW 264.7 cells and inhibiting expression of IL-1beta and TNF-alpha mRNA. Researches of anti-inflammatory mechanisms prove that the strictosamide can inhibit LPS-stimulated NF-kappaB and MAPK signal paths in RAW 264.7 cells.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of vinblastam in the preparation of anti-inflammatory drugs. Background technique [0002] Nauclea officinalis Pierre ex Pitard, also known as ebony, is the dry rhizome of Nauclea officinalis Pierre ex Pitard, which is mainly distributed in Hainan, Guangdong, Guangxi and other provinces of my country. It is bitter and cold in nature and has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. It is commonly used in the treatment of colds, fever, pneumonia, enteritis, dysentery, eczema, rashes, abscesses and other diseases. It has been reported in the literature that birchwood mainly contains alkaloid components, and Strictosamide is the alkaloid component with the highest content (Fenxia Zhu * , Jiaquan Chen, Hui Wang, et al Journal of Chromatography B, 2015, 1007: 54-66; Hu Xin. Separation and analysis of chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P29/00
CPCA61K31/706
Inventor 朱粉霞叶霁青陈家全翟小婷贾晓斌
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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