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Traditional Chinese medicine inhalation aerosol for treating asthma and preparation method and application thereof

An aerosol and suspension aerosol technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of lack of safety and compliance of injections, and avoid liver first Over-effect, quick onset and convenient administration

Active Publication Date: 2016-12-21
JIANGSU SUZHONG PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Years of clinical use have shown that Zhichuanling injection has a good effect in treating asthma, but the injection is deficient in safety and compliance

Method used

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  • Traditional Chinese medicine inhalation aerosol for treating asthma and preparation method and application thereof
  • Traditional Chinese medicine inhalation aerosol for treating asthma and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A traditional Chinese medicine inhalation aerosol for treating asthma, comprising the following components by weight percentage:

[0032] (1) 64.5% of the active ingredients obtained from ephedra, daphnia, forsythia and bitter almond through water extraction and alcohol precipitation;

[0033] (2) Solubilizer Span 0.5%;

[0034] (3) Propellant tetrafluoroethane 35%.

[0035] The preparation method is as follows:

[0036] Take 10 parts of ephedra, 1 part of Yangjinhua, 10 parts of forsythia, 10 parts of bitter almond, add water and decoct twice, the first time for 1 hour, and the second time for 0.5 hours, combine the decoction, filter, and use the filtrate after concentration Ethanol precipitation treatment twice, the alcohol content in the first solution is 75%, and the second time is 90%. Each time, each time it is refrigerated at 4°C for 24 hours, filtered, the filtrate is concentrated, add Span, mix well, pour Pack, press into tetrafluoroethane.

Embodiment 2

[0038] A traditional Chinese medicine inhalation aerosol for treating asthma, comprising the following components by weight percentage:

[0039] (1) 33.5% of active ingredients obtained from ephedra, daphnia, forsythia and bitter almonds through water extraction and alcohol precipitation;

[0040] (2) Solubilizer oleic acid 1.5%;

[0041] (3) Propellant heptafluoroethane 65%.

[0042] The preparation method is as follows:

[0043] Take 15 parts of Ephedra, 3 parts of Yangjinhua, 15 parts of Forsythia, and 15 parts of Bitter Almond, add water and decoct twice, the first time for 1 hour, and the second time for 0.5 hours, combine the decoction, filter, and use the filtrate after concentration Ethanol precipitation treatment twice, the alcohol content in the first solution is 70%, and the second time is 85%, each time it is placed in cold storage at 2°C for 24 hours, filtered, the filtrate is concentrated, oleic acid is added, mixed evenly, poured Pack, press into the heptaflu...

Embodiment 3

[0045] A traditional Chinese medicine inhalation aerosol for treating asthma, comprising the following components by weight percentage:

[0046] (1) 8% of the active ingredients obtained from ephedra, daphnia, forsythia and bitter almond through water extraction and alcohol precipitation;

[0047] (2) Solubilizer Tween 2%;

[0048] (3) Propellant compressed air 90%.

[0049] The preparation method is as follows:

[0050] Take 20 parts of ephedra, 5 parts of Yangjinhua, 20 parts of forsythia, 20 parts of bitter almonds, add water and decoct twice, the first time for 1 hour, the second time for 0.5 hours, combine the decoction, filter, and use the filtrate after concentration Ethanol precipitation treatment was performed twice, the alcohol content in the first solution was 65%, and the second time was 80%. Each time, it was placed in a refrigerator at 4°C for 24 hours, filtered, the filtrate was concentrated, Tween was added, mixed evenly, poured Install, press in compressed ...

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Abstract

The invention discloses traditional Chinese medicine inhalation aerosol for treating asthma. The traditional Chinese medicine inhalation aerosol for treating asthma is prepared from, by weight, 5%-69.5% of effective ingredients obtained from ephedra, flos daturae, fructus forsythia and semen armeniacae amarae through water extraction and alcohol precipitation, 0%-30% of cosolvent, 0.5%-2% of solutizer and 30%-90% of propellant. The traditional Chinese medicine inhalation aerosol for treating asthma has the effects of freeing the lung and relieving asthma, and expelling phlegm to arrest coughs, is clinically used for asthma caused by turbid phlegm lung obstructing and impairment of dispersing and descending function of the lung, coughs, and chest oppression and excessive phlegm; bronchial asthma and asthmatic bronchitis have the syndromes. Compared with an existing preparation, the traditional Chinese medicine inhalation aerosol directly enters the lung, and has the advantages of being rapid in effect taking, efficient and the like.

Description

technical field [0001] The invention relates to an inhalation aerosol for treating asthma and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Asthma is one of the most common chronic respiratory diseases in the world today. "Jingyue Quanshu · Breathing and Cushing" says: "Asthma has a long-standing root, and it will come out when it is cold, or it will come out when it is tired, and it is also called asthma." Bronchial asthma is the most common chronic respiratory disease characterized by airway hyperresponsiveness. In recent years, its morbidity and mortality have increased, especially in children with asthma. According to the World Health Organization (WHO) estimates, there are approximately 300 million asthmatics worldwide. Prevention and treatment of asthma has become a global public health problem. Systemic or local administration of glucocorticoids is still the first choice for the treatment of asthma in modern medicine, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/72A61P11/06A61P11/10A61P11/14A61P11/00
CPCA61K9/0078A61K36/17A61K36/634A61K36/736A61K36/81A61K47/06A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 唐仁茂王丹丹赵耕先葛海涛陈俊
Owner JIANGSU SUZHONG PHARM GRP CO LTD
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