A kind of artemether suppository and preparation method thereof
A technology for artemether and suppositories, which is applied in the field of artemether suppositories and its preparation, which can solve the problems of affecting absorption and drug efficacy, small drug loading, and easy slipping of cataplasms, and achieve high bioavailability, ease of use and ease of use. Easy to carry and avoid the first-pass effect
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[0037] The preparation method of the artemether suppository of the present invention comprises the steps of oil phase preparation, water phase preparation and suppository preparation, specifically comprising:
[0038] A. Oil phase preparation: add artemether that has been finely ground and passed through a 80-120 mesh sieve to the peanut oil in the formula ratio at 25-45°C, stir and dissolve to obtain oil phase a;
[0039] B. Preparation of water phase: Take the polyethylene glycol 400, polyethylene glycol 4000 and polyoxyethylene monostearate in the proportion of the formula, melt them completely at 45~65°C, and mix them uniformly to obtain the water phase b;
[0040] C. Suppository preparation: Take the Tween-80, poloxamer and additives in the formula ratio and pour them into the fully melted matrix water phase b, stir and mix, then add the oil phase a, stir evenly to obtain emulsion c, and mix the emulsion c. Pour it into a plug mold, cool it in an environment below 30°C, a...
Embodiment 1
[0125] Artemether 1 g, polyethylene glycol 400 5 g, polyethylene glycol 4000 12 g, peanut oil 6 g, Tween-80 0.8 g, polyoxyethylene (40) monostearate 1 g, porol Sham 1 g
[0126] In a water bath at 25°C, gradually add artemether that has been finely ground and passed through a 80-mesh sieve to peanut oil, and stir as it is added to dissolve the main ingredient completely, and use it as the oil phase; take PEG400, PEG4000, polyoxyethylene (40) Monostearic acid esters are completely melted in a water bath at 50°C, and mixed evenly, as the water phase; an appropriate amount of Tween-80, poloxamer and other additives are slowly poured into the completely melted matrix, and continuously Stir to make the matrix and emulsifier completely mixed; slowly add the oil phase to the water phase matrix mixed with emulsifier, add slowly, and keep stirring at a speed of 60r / s for a certain period of time to make it a uniform emulsion; It is advisable to pour the above-mentioned molten plug int...
Embodiment 2
[0128] Artemether 90 g, Macrogol 400 300 g, Macrogol 4000 500 g, Peanut Oil 240 g, Tween-8060 g
[0129] At 45°C, gradually add artemether that has been finely ground and passed through a 120-mesh sieve into peanut oil, and stir as it is added, so that the main ingredient is completely dissolved and used as the oil phase; take PEG400 and PEG4000, melt them completely at 60°C, and Mix evenly and use it as the water phase; weigh an appropriate amount of Tween-80 and slowly pour it into the completely melted matrix, and keep stirring to completely mix the matrix and the emulsifier; slowly add the oil phase to the mixture mixed with the emulsifier Slowly add to the aqueous phase matrix, and stir for a certain period of time to make it a uniform emulsion; pour the above-mentioned molten plug into the plug mold, and it is advisable to pour it until the mold mouth overflows slightly; cool it in an environment below 30°C, and take it out , Gently scrape off the excess, take out the ar...
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Abstract
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