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Pharmaceutical composition for resisting mycobacterium tuberculosis, and preparation method of pharmaceutical composition

A composition and drug technology, applied in the field of medicine, can solve problems such as the material basis that is not yet clear, and achieve the effects of strong anti-mycobacterium tuberculosis effect and easy operation

Inactive Publication Date: 2017-01-04
JIUZHITANG
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

In the past two years, there have been a small number of studies on the anti-tuberculosis effect of the nude flower purple pearl, such as "in vitro antibacterial effect of nude flower purple pearl on clinical isolation of Mycobacterium tuberculosis" (Chinese Journal of Traditional Chinese Medicine, 2014, 29 (11): 3630-3632), "Studies on Astringent Hemostasis and Antibacterial Effect on Mycobacterium Tuberculosis" (Hunan Normal University, 2014 Master's Thesis), a preliminary study on the effect of dried extract of Nude Flower Purple Pearl on Mycobacterium tuberculosis role, but its material basis has not yet been clarified

Method used

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  • Pharmaceutical composition for resisting mycobacterium tuberculosis, and preparation method of pharmaceutical composition
  • Pharmaceutical composition for resisting mycobacterium tuberculosis, and preparation method of pharmaceutical composition
  • Pharmaceutical composition for resisting mycobacterium tuberculosis, and preparation method of pharmaceutical composition

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Embodiment Construction

[0019] The following will be further described in detail with examples. The inventors obtained corresponding examples and comparative examples through different preparation processes, and measured the MIC values ​​of the examples, comparative examples, and positive control drugs. See Table 1 for details.

[0020] The inventor makes embodiment by following process:

[0021] 1. Preparation of effective part B of Auranthus nudiflora petroleum ether extraction:

[0022] (1) Take the medicinal material of Aurora nudiflorum, grind it into a coarse powder, add 90%-95% ethanol and heat and reflux for extraction 1-3 times to obtain an extract, and after filtering, the obtained filtrate is concentrated into an extract A,

[0023] (2) The extract A obtained in step (1) is uniformly dispersed in water, added petroleum ether for extraction, removed the solvent, concentrated, and dried to obtain the effective part B of petroleum ether extraction,

[0024] 2. Preparation of Auranthus nudifl...

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Abstract

The invention discloses a folium callicarpae nudiflorae pharmaceutical composition and use thereof. The pharmaceutical composition is prepared from 1 part of petroleum ether extract effective part B from folium callicarpae nudiflorae and 3-5 parts of folium callicarpae nudiflorae extract C. The pharmaceutical composition provided by the invention has a stronger function of resisting mycobacterium tuberculosis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition with anti-tuberculosis effect and a preparation method thereof. Background technique [0002] Callicarpa nudiflora Hook.et Arn. is a plant of the genus Callicarpa nudiflora Hook.et Arn. It is produced in Hainan, Guangxi, Guangdong, India, Vietnam, Malaysia and other places. Its roots and leaves can be used as medicine and have astringent properties. Hemostasis, anti-inflammatory and detoxification effects. In the past two years, there have been a small number of studies on the anti-tuberculosis effect of the nude flower purple pearl, such as "in vitro antibacterial effect of nude flower purple pearl on clinical isolation of Mycobacterium tuberculosis" (Chinese Journal of Traditional Chinese Medicine, 2014, 29 (11): 3630-3632), "Studies on Astringent Hemostasis and Antibacterial Effect on Mycobacterium Tuberculosis" (Hunan Normal University, 2014 Master's Thes...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P31/06
Inventor 黄胜谷陟欣颜冬兰陈四娟叶惠煊
Owner JIUZHITANG
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