A kind of anti-tuberculosis traditional Chinese medicine compound and its preparation method

An anti-tuberculosis and traditional Chinese medicine technology, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of easy recurrence, drug resistance, damage, etc. The effect of resistance

Active Publication Date: 2018-06-08
JIUZHITANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently widely used anti-tuberculosis drugs are isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin, rifapentine, etc. Patients develop drug resistance and drug resistance due to long treatment time , and there are side effects of damage to the liver, kidney, etc. For the treatment of extrapulmonary tuberculosis (such as bone tuberculosis, tuberculous meningitis), chemotherapy or surgery is usually used. to suffer physically and mentally
At present, there is no report on the anti-tuberculosis staging bacillus effect of nude flower purple pearl in vivo and in vitro, and there is no report on the anti-tuberculosis staging bacillus effect of the compound prepared by nude flower purple pearl combined with other traditional Chinese medicines

Method used

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  • A kind of anti-tuberculosis traditional Chinese medicine compound and its preparation method
  • A kind of anti-tuberculosis traditional Chinese medicine compound and its preparation method
  • A kind of anti-tuberculosis traditional Chinese medicine compound and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Injection

[0058] prescription:

[0059] Nadihua Zizhu (fresh, leaves and twigs, dry rate 33.2%) 563g Schisandra (fresh, fruit, dry rate 26.7%) 300g sodium chloride 7g Tween-80 5g Add water for injection to 1000ml

[0060] Preparation method:

[0061] Take Schisandra chinensis (fresh), add 1 times the amount of 90% ethanol to extract twice, each time for 1.5 hours, filter, combine the filtrates, concentrate to a clear paste with a relative density of 1.03~1.10 (60°C);

[0062] Add 1.5 times the amount of water to crush into a homogenate, squeeze, filter, and concentrate the squeezed liquid to a clear paste with a relative density of 1.03~1.10 (60°C);

[0063] Combine Schisandra Clear Cream and Nude Flower Purple Pearl Clear Cream, add ethanol until the alcohol content reaches 50%, stir, refrigerate, precipitate, filter, recover ethanol from the filtrate, concentrate to 500ml, add ethanol until the alcohol content reaches 80%, Refrigerate for 24 hours, filt...

Embodiment 2

[0064] Example 2 Aerosol

[0065] prescription:

[0066] Nadihua Zizhu (fresh, leaves and twigs, dry rate 33.2%) 683.6g Schisandra (fresh, fruit, dry rate 26.7%) 150g Difluorodichloromethane Proper amount Ethanol

[0067] Preparation method:

[0068] Add 0.5 times the amount of water to crush the naked flower purple pearl into a homogenate, squeeze and filter to obtain the squeezed liquid, add 1 times the amount of 90% ethanol to the remaining squeezed residue to extract once, filter after extraction, get the filtrate, and combine the filtrate and the squeezed liquid , concentrated to a liquid extract with a relative density of 1.15~1.35 (60°C), combined with the liquid extract obtained from the squeezed liquid;

[0069] Take Schisandra chinensis and add 2 times the amount of 90% ethanol to extract twice, each time for 2 hours, filter, and concentrate the liquid extract with a relative density of 1.10~1.15 (60°C);

[0070] Combine Nadihuazizhu and Schisandra liquid extract,...

Embodiment 3

[0071] Example 3 Spray

[0072] prescription:

[0073] Nudihua Zizhu (fresh, leaves and twigs, 33.2% dried) 521.8g Schisandra (fresh, fruit, 26.7% dried) 519.1g Old Crow Paste (fresh, leaves and twigs, 31.5% dried) 10g paraben 0.25 g

[0074] Preparation method:

[0075] Add 3 times of water to the Nudehuazizhu and Laoya paste to crush into a homogenate, squeeze, filter, concentrate the squeezed liquid to a relative density of 1.03~1.06 (60°C), add 5 times the amount of 90% ethanol to extract the remaining squeezed residue once , filtered after extraction to obtain the filtrate, which was concentrated to a relative density of 1.03~1.06 (60°C);

[0076] Take Schisandra chinensis and add 8 times the amount of 50% ethanol to extract twice, each time for 2 hours, filter, and concentrate the liquid extract with a relative density of 1.10~1.15 (60°C);

[0077] Combine the clear ointment of the three medicinal materials, add paraben, dissolve, filter, add distilled water to 1000m...

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PUM

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Abstract

The invention provides a traditional Chinese medicine. The main raw material of the traditional Chinese medicine is the naked flower purple pearl, which can be prepared by combining with the raw materials of schisandra chinensis, old crow paste and the like. The traditional Chinese medicine of the invention has the effect of resisting mycobacterium tuberculosis, and also discloses a preparation method of the traditional Chinese medicine.

Description

technical field [0001] The invention relates to an anti-tuberculosis medicine, in particular to an anti-tuberculosis traditional Chinese medicine compound and a preparation method thereof. Background technique [0002] Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis can affect multiple organs throughout the body, but pulmonary tuberculosis is the most common. Currently widely used anti-tuberculosis drugs are isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin, rifapentine, etc. Patients develop drug resistance and drug resistance due to long treatment time , and there are side effects of damage to the liver, kidney, etc. For the treatment of extrapulmonary tuberculosis (such as bone tuberculosis, tuberculous meningitis), chemotherapy or surgery is usually used. Come physically and mentally. In order to overcome the above problems, the invention provides a traditional Chinese medicine with short medication time, low cost an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/85A61P31/06
Inventor 谷陟欣陈珍贵袁莉冯星黄胜李伟刘翀周覃
Owner JIUZHITANG
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