Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of cochliodinol in preparing anticoagulant drugs

An anticoagulant and mycin technology, which is applied to the application field of the secondary metabolite Kojimycin in the preparation of anticoagulant drugs of C. tortoise, can solve the problems of large toxic and side effects, few industrialized production, low purity and the like

Active Publication Date: 2017-02-08
HUANGHE S & T COLLEGE
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the raw materials for the isolation of natural products are scarce and of low purity, and are rarely used in industrialized production; modification of natural products by chemical synthesis can strengthen the affinity and specificity of enzymes, but they have great toxic and side effects on the human body.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of cochliodinol in preparing anticoagulant drugs
  • Application of cochliodinol in preparing anticoagulant drugs
  • Application of cochliodinol in preparing anticoagulant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] 1.1 Experimental animals

[0011] Rex rabbits, male, weighing 2.0-2.5 kg, were adaptively fed for one week. The temperature is 25±2 ℃, the light is 12 hours / day, the humidity is 40~45%, and the animals are free to drink and eat.

[0012] 1.2 Instrument Reagents

[0013] HF6000-4 semi-automatic coagulation analyzer (Southern Hanfang Medical Devices Co., Ltd.); TGL-16gR high-speed desktop refrigerated centrifuge (Shanghai Anting Scientific Instrument Factory); electronic balance (Mettle-Toledo, USA), sodium chloride injection ( Hebei Tiancheng Pharmaceutical Co., Ltd., A14091701); 0.109 mol / L sodium citrate solution (self-made), vitamin K 1 Injection (Tianjin Pharmaceutical Group Xinzheng Co., Ltd., 1403112); Breviscapine for injection (Hunan Hengsheng Pharmaceutical Co., Ltd., 20110202); Prothrombin time (PT) assay kit (105241); Activated partial thrombin time ( APTT) assay kit (112175); thrombin time (TT) assay kit (121132); fibrinogen (FIB) content assay kit (132070...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of microbial secondary metabolite applications and particularly relates to the application of cochliodinol, as a chaetomium spirale strain secondary metabolite, in preparing anticoagulant drugs. The chaetomium spirale strain generates a large number of secondary metabolites based on its own unique biosynthetic pathway, so that the industrial production can be achieved. Meanwhile, the sustainable development is enabled. The TT ((i) p & < 0.001 (i)) can be significantly prolonged by the cochliodinol. Meanwhile, the FIB ((i) p & < 0.001 ( i)) can be significantly reduced by the cochliodinol. Therefore, the blood coagulation can be inhibited through prolonging the thrombin time and reducing the content of fibrinogen in the plasma. The cochliodinol has a potential value for the development of anticoagulant drugs.

Description

technical field [0001] The invention belongs to the technical field of application of secondary metabolites of microorganisms, and in particular relates to the application of canjunamycin, a secondary metabolite of stenotic hair shells, in the preparation of anticoagulant drugs. Background technique [0002] Chaetomium angustispirale belongs to the Ascomycota genus Chaetomycota, which is distributed worldwide and has important economic value and ecological significance. Studies have shown that Chaetomium, as a biocontrol fungus, can play an active role in the prevention and control of plant diseases, and most of them have the ability to degrade cellulose. In addition, Chaetomium has important medical value. During the metabolic process of the endophytic Chaetomyces isolated from Maytan wood plants, chaetin, which has significant anticancer effects, can be produced. Corgamycin is a secondary metabolite of trichomes (the preservation taxonomic name is trichomes CLC001, the pr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/404A61P7/02
CPCA61K31/404
Inventor 陈林郭继倩康文艺
Owner HUANGHE S & T COLLEGE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com