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Keratin-chitosan composite medical dressing and preparation method thereof

A technology of keratin and chitosan, applied in the direction of keratin, cytokeratin, mammalian protein, etc., to achieve excellent technical effects, accelerate wound healing, and avoid re-injury effects

Inactive Publication Date: 2017-02-22
北京东方艾美生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the applicant has found that keratin itself has many advantages after many years of research, there is still a lot of room for improvement in terms of repairing effect when it acts alone

Method used

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  • Keratin-chitosan composite medical dressing and preparation method thereof
  • Keratin-chitosan composite medical dressing and preparation method thereof
  • Keratin-chitosan composite medical dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A keratin and chitosan composite medical dressing, the ingredients of the dressing and the mass percentages of various ingredients are added according to the following mass percentages: keratin: 2%; sodium carboxymethyl cellulose: 1%; chitosan: 0.3% ; Glycerin: 8%; The balance is water. Wherein, the keratin is granular keratin prepared from human hair, and the granular keratin is powdery keratin.

Embodiment 2

[0047] A kind of keratin, chitosan composite medical dressing, the components of the dressing and the quality of various components are added according to the following mass percentages: keratin: 8%; sodium carboxymethyl cellulose: 0.6%; chitosan: 0.9% ; Glycerin: 6%; The balance is water. Wherein, the keratin is granular keratin prepared from wool, and the granular keratin is powdery keratin.

Embodiment 3

[0049] A keratin and chitosan composite medical dressing, the components of the dressing and the mass percentages of various components are added according to the following mass percentages: keratin: 4%; sodium carboxymethyl cellulose: 0.9%; chitosan: 0.6% ; Glycerin: 6.5%; The balance is water.

[0050] Wherein, the keratin is 3% gelatinized keratin prepared from wool, and the preparation method of the gelatinized keratin is: add 200 mg of granular keratin prepared from wool to 5 ml of water, Mix well, place in an incubator and incubate at 37°C until a relatively uniform color and character appear; sterilize to obtain gelled hair keratin with a concentration of 4%. Figure 6 It is the property of gelled hair keratin at a concentration of 4%.

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Abstract

The invention relates to a keratin-chitosan composite medical dressing and a preparation method thereof; the dressing is prepared from, by weight, 2-8% of keratin, 0.6-1% of sodium carboxymethyl cellulose, 0.3-0.9% of chitosan, 6-8% of glycerol, and the balance of water. The preparation method comprises: adding keratin and sodium carboxymethyl cellulose into water, adding chitosan and glycerol, mixing well, and performing first lyophilizing; soaking sequentially in CaCl2 solution and NaOH solution, and performing second lyophilizing after soaking is complete; soaking in glycerol aqueous solution, and performing third lyophilizing after soaking is complete. The keratin-chitosan composite medical dressing prepared herein has no immunogenicity, is good in hemostatic effect and high in air permeability, and also has the advantages, such as good biocompatibility and the ability to promote cell growth.

Description

technical field [0001] The invention relates to a dressing, in particular to a keratin-chitosan composite medical dressing and a preparation method thereof. Background technique [0002] In the existing technology and materials, the relevant medical dressings are usually composed of non-woven fabrics, absorbent paper, wadding, and leak-proof membranes. This kind of paper-type medical dressings has a large amount of liquid absorption, does not change shape after absorbing liquids, and does not break or break. . However, if this medical dressing is used for infants, scalds, and burn patients, the dressing is easy to adhere to the wound, is not easy to peel off, and is not absorbed by human tissue. Therefore, the applicant regards the construction of a matrix and scaffold system that simulates body tissues and functions as the focus of scientific research, and rebuilds or restores the skin barrier as the ultimate goal of wound treatment. Biological dressings are currently the...

Claims

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Application Information

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IPC IPC(8): A61L26/00C07K14/47C07K1/14
CPCA61L26/0095A61L26/0066A61L26/0085A61L26/009A61L2300/252A61L2300/404A61L2300/412A61L2300/604C07K14/4741C08L1/286C08L5/08
Inventor 张娇张飞郑秋
Owner 北京东方艾美生物技术股份有限公司
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