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Myeloma signal path mechanism confirming method based on modular factor graph

A signal pathway and factor graph technology, applied in the field of systems biology, can solve problems such as low accuracy and inability to use biological computing, and achieve the effect of improving understanding, realizing prediction, and reducing computing costs.

Active Publication Date: 2017-03-15
SOUTHWEST UNIVERSITY
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Problems solved by technology

[0012] (1) Judging by human experience, the accuracy rate is not high
[0013] (2) Mathematical methods such as ODE only describe the change of biomass, and cannot directly display the structural characteristics of biological systems in a graphical way
[0014] (3) The standard Petri Net is often used to qualitatively analyze the structural properties of biological networks and cannot be used for biological computing

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  • Myeloma signal path mechanism confirming method based on modular factor graph
  • Myeloma signal path mechanism confirming method based on modular factor graph
  • Myeloma signal path mechanism confirming method based on modular factor graph

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Embodiment Construction

[0076] Embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. It should be clear that the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0077] Those skilled in the art should know that the following specific embodiments or specific implementation methods are a series of optimized configurations listed by the present invention to further explain the specific content of the invention, and these configurations can be combined with each other or used in association with each other, unless it is clearly stated in the present invention that some or a specific embodiment or implementation cannot be associated with or used in conjunction with other embodiments or ...

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Abstract

The invention provides a myeloma signal path mechanism confirming method based on a modular factor graph. The method comprises the steps that 1, RPPA data is obtained; 2, the RPPA data is preprocessed, and key proteins are screened in a coarse-grained mode; 3, based on the key proteins screened in the coarse-grained mode, mutual effect channels of proteins in cells in a rigid cell environment are established to form signal channels; 4, an ordinary differential equation is adopted to describe the signal channels, the signal channels are decomposed into multiple small modules, and parameter optimization is conducted on the small modules to establish a system biology model; 5, parameter analysis is conducted on the system biology model, wherein the parameter analysis includes stability analysis and sensitivity analysis. By the adoption of the method, the calculation cost of the system model in signal channel detection is effectively reduced, and the calculation efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of systems biology, mainly relates to bioinformatics and biological data mining, and specifically relates to a method for confirming a signal pathway mechanism based on a modular factor graph. Background technique [0002] Multiple myeloma (MM) is a malignant tumor characterized by the clonal proliferation of malignant plasma cells, and is currently the second most common malignant tumor in the blood system. The current treatment of MM mainly includes traditional chemotherapy, new drug targeted therapy and immunotherapy. Although the new targeted therapy has significantly improved the efficacy of MM, the median survival time of patients is still 3 to 5 years, and its pathogenesis is still unclear. Therefore, it is an urgent problem to further study the relevant mechanism affecting the growth of MM cells and to find a model research method. [0003] No matter from the perspective of biology or clinical mani...

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Application Information

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IPC IPC(8): G06F19/12
CPCG16B5/00
Inventor 章乐孔美静
Owner SOUTHWEST UNIVERSITY
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