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Medicine for treating ischemic stroke and its preparation method and use

A technology for ischemic stroke and drugs, applied in the field of drugs, to achieve the effect of reducing brain atrophy, inhibiting cell apoptosis and necrosis signaling pathways, and reducing the volume of cerebral infarction

Active Publication Date: 2019-08-13
山东蓝康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, NADPH and NAD were not seen + A report on combined application in the treatment of cerebral ischemic stroke

Method used

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  • Medicine for treating ischemic stroke and its preparation method and use
  • Medicine for treating ischemic stroke and its preparation method and use
  • Medicine for treating ischemic stroke and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The pharmaceutical composition for the treatment of cerebral apoplexy in this embodiment, its raw material consists of: NADPH2.5g, NAD + 50g;

[0053] Its preparation method comprises the following steps: take selected weights of NADPH and NAD respectively + , mix evenly, that is.

Embodiment 2

[0055] The pharmaceutical composition for the treatment of cerebral apoplexy in this embodiment, its raw material consists of: NADPH7.5g, NAD + 50g;

[0056] Its preparation method comprises the following steps: take selected weights of NADPH and NAD respectively + , mix evenly, that is.

Embodiment 3

[0058] The pharmaceutical composition for the treatment of cerebral apoplexy in this embodiment, its raw material consists of: NADPH1g, NAD + 55g;

[0059] Its preparation method comprises the following steps: take selected weights of NADPH and NAD respectively + , mix evenly, that is.

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Abstract

A pharmaceutical composition for treating ischemic stroke and a preparation method and use thereof. The active pharmaceutical ingredients of the pharmaceutical composition include: 0.05-20 parts by weight of NADPH, and 10-100 parts by weight of NAD+.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to medicaments for treating ischemic cerebral apoplexy, a preparation method and application thereof. Background technique [0002] NAD, chemically known as nicotinamide adenine dinucleotide or nicotinic acid diphosphate, exists in the oxidized form (NAD + ) and reduced (NADH), it is an important coenzyme in the redox reaction of the human body and belongs to coenzyme I; at the same time, it is NAD + There are three main types of enzymes in the body: (1) ADP-ribosyltransferase or polyribose-based polymerase (PARP); (2) cyclic ADP-ribose synthase (cADPR synthases ); (3) III protein type lysine deacetylase Sirtuins. These enzymes convert coenzyme I (NAD + ) is decomposed into ADP ribose and nicotinamide (Nam) as a substrate, and exerts different physiological functions in different cells. NAD + It is an important cofactor for cellular energy production. Mitochondria can tra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7084A61P9/10A61P1/16A61P13/12A61P9/00
CPCA61K31/7084A61K2300/00
Inventor 秦正红孙美玲
Owner 山东蓝康药业有限公司
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