Medicine composition used for treating lymphoma and application

A composition and medicine technology, applied in the field of traditional Chinese medicine, can solve the problems such as frequent loose stools, lack of Pulsatilla japonica, inability to achieve therapeutic effect, etc., and achieve the effects of reducing liver and kidney toxicity and increasing body weight.

Inactive Publication Date: 2017-03-29
徐修山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, large doses can cause loss of appetite, loose stools and more frequent reactions
At present, there is still a lack of compatible prescriptions for Pulsatillae, and the simple use of Pulsatilla and its extracts still cannot achieve a good therapeutic effect

Method used

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  • Medicine composition used for treating lymphoma and application
  • Medicine composition used for treating lymphoma and application
  • Medicine composition used for treating lymphoma and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Chinese medicine formula and decocting

[0022] The pharmaceutical compositions of test groups 1-5 were prepared according to the formula shown in Table 1, and the quantity units in the table are all grams.

[0023] Table 1: The formula of the pharmaceutical composition of the present invention:

[0024]

[0025]

[0026] The medicinal composition that above-mentioned traditional Chinese medicine is formed is placed in pottery pot and decocts to make the concoction of about 500 milliliters. The specific decocting method is to put the traditional Chinese medicine in a clay pot, add 1-2 cm of water submerged in the medicinal material, heat to boiling on high heat and turn to low heat to heat for 30 minutes. After extracting the concoction, add water and repeat the above steps. Finally obtain about 500 milliliters of concoction. All traditional Chinese medicines were purchased from Tong Ren Tang unless otherwise stated.

Embodiment 2

[0027] Embodiment 2: drug effect animal test

[0028] The human Burkitt lymphoma cell line Daudi was injected into mice through the tail vein to explore the establishment of a mouse model of lymphoma. The specific test method can be found in "Chinese Journal of Cancer", 2009, 28(2): 217-220. By using this method, 6 groups of test mice were obtained, each with 8 mice, all of which were ten-week-old female mice (injected at six-week-old and used after four weeks). A course of treatment (15 days) of medication was carried out to the above mice. The way of administration is to use a syringe to perform oral perfusion feeding on the mice, once every morning at 09:00 and 21:00 respectively.

[0029] Before and after the treatment, the body weight of the mice was measured respectively, and after the drug-taking treatment period of the mice was over, the mice were killed and their formed lymphomas were surgically removed, and the fresh lymphomas were weighed. Table 2 shows the effec...

Embodiment 3

[0035] Embodiment 3: liver toxicity test

[0036]According to reports, feeding rats with feed containing Alisma extracts will cause turbidity, swelling and hyaline degeneration in the liver of the rats, and swelling and vacuoles in the epithelial cells of the proximal convoluted tubules of the kidneys. After the mice of each experimental group described in Example 2 were sacrificed, their livers were dissected to obtain their livers, and the hyaline degeneration state of swelling of their livers was observed. It was found that no obvious liver swelling and hyaline degeneration were observed in the drugs of test groups 4 and 5, but obvious liver swelling and hyaline degeneration appeared in test group 3. Liver swelling and hyaline degeneration were less severe in test groups 1-2, but present. This shows that when the amount of Alisma drug used is increased, the therapeutic effect of lymphoma is promoted, but at the same time, severe liver toxicity is caused, and serious lesion...

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PUM

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Abstract

The invention provides a medicine composition used for treating lymphoma and an application thereof. The medicine composition is composed of root of Chinese pulsatilla, common selfheal fruit-spike, rhizoma atractylodis, atractylodes macrocephala koidz, light red tuckahoe, polyporus umbellatus, rhizoma alismatis, pericarpium citri reticulatae, rhiizoma dioscoreae, hyacinth beans, fried coix seeds, liquorice, talcum powder, rhizoma dioscoreae colletii and polygonum aviculare. The medicine composition has the effects of treating lymphoma and improving patient weight and has wide prospects in the aspects of therapeutic medicines and health care products.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating lymphoma and its application. Background technique [0002] 1. Lymphoma [0003] Malignant lymphoma, also known as "lymphoma", is a malignant tumor that originates in lymph nodes or other lymphoid tissues. It is one of the ten most common malignant tumors in my country. The disease is more common in middle-aged and young people, and there are more male patients than females. The disease can be divided into Hodgkin's disease and non-Hodgkin's lymphoma according to its different cellular components. The degree of malignancy varies, and it is caused by the malignant proliferation of the lymphoid-histiocytic system, which mostly occurs in the cervical lymph nodes. [0004] The manifestation of malignant lymphoma is mainly swollen lymph nodes on the body. It is not painful or itchy in the early stage, so it is often ign...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61P35/00A61K33/12
CPCA61K36/71A61K33/12A61K36/07A61K36/076A61K36/284A61K36/48A61K36/484A61K36/536A61K36/704A61K36/752A61K36/884A61K36/8945A61K36/8994A61K2300/00
Inventor 徐修山
Owner 徐修山
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