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Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease

A technology for chronic obstructive pulmonary disease and traditional Chinese medicine preparations, which can be used in pharmaceutical formulations, respiratory diseases, and medical preparations containing active ingredients. levels and oxidative stress, and the effect of improving lung function

Inactive Publication Date: 2017-04-05
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of the above-mentioned preparations, there are defects such as stable quality, inconvenient storage, and inaccurate curative effects in practice. Based on this, the inventor of the present application intends to provide an effective treatment for COPD with stable quality, definite curative effect, and easy storage and use. Traditional Chinese medicine preparation and preparation method thereof

Method used

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  • Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease
  • Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease
  • Traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: preparation tablet

[0040] Take 10kg of dried ginger, crush it, pass through a 20-30 mesh sieve, add 10 times the amount of water, soak for 30 minutes, distill and extract the volatile oil for 5 hours, and collect the volatile oil; take 6 times the amount of volatile oil (g / ml)) Hydroxypropyl-β-cyclo For dextrin, add water to make the concentration of hydroxypropyl-β-cyclodextrin 5%, heat to dissolve, let cool to 45°C, keep the temperature constant, add volatile oil (dissolved in a small amount of ethanol), stir for 2h, let cool to room temperature, and refrigerate for 24h , filtered, dried at 40°C, and finely ground to obtain clathrates; 60kg of dried ginger dregs and earthworm, 5kg of Tiannanxing, added water to extract twice, adding 9 times the amount of water each time, 45min each time, combined decoction, Filtrate, concentrate the filtrate to obtain extract; take another 25kg of Scutellaria baicalensis, crush it, pass through a 100-mesh sieve, add th...

Embodiment 2

[0041] Embodiment 2: preparation tablet

[0042] Take 8kg of dried ginger, crush it, pass through a 10-20 mesh sieve, and use CO 2Supercritical extractor extraction, extraction pressure 20Mpa, separation temperature 45 ° C, extraction time 1h, collect volatile oil; take 5 times the amount of volatile oil (g / ml)) β-cyclodextrin, add 15 times the amount of volatile oil (g / ml ) water, grind well, add volatile oil (dissolved in a small amount of ethanol), grind for 45 minutes to a paste, filter, dry at 40°C, and grind finely to obtain an inclusion compound; 80kg of medicinal dregs and earthworm are extracted twice by adding water, each time adding 10 Double the amount of water, 45 minutes each time, combine the decoction, filter, concentrate the filtrate, and obtain the extract; take another 24kg of Scutellaria baicalensis and 12kg of Radix Scutellariae, crush them through an 80-mesh sieve, add the extract to the above powder, make granules, and dry , granulated, added with clath...

Embodiment 3

[0043] Embodiment 3: preparation tablet

[0044] Take 8kg of dried ginger, crush it, pass through a 20-30 mesh sieve, add 10 times the amount of water, soak for 0.5h, distill and extract the volatile oil for 4h, and collect the volatile oil; 70kg of medicinal dregs and earthworm, 10kg of scutellaria baicalensis, 12kg of scutellaria baicalensis, add water to extract three times, Add 8 times of water each time, 30 minutes each time, filter the decoction, combine, concentrate the filtrate under reduced pressure, and dry it in vacuum to get a dry cream powder, take the volatile oil and dissolve it in 70% ethanol, make granules, add an appropriate amount of microcrystalline cellulose, and press into tablets , that is.

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Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease. The preparation takes Lumbricus, dried ginger, root of large-flowered skullcap and prepared rhizoma arisaematis tuber as effective components, the dried ginger is individually extracted to obtain volatile oil, the herb residue, other bulk drugs, pharmaceutic adjuvants and volatile oil are prepared to obtain an oral solid preparation, through test and clinic confirmation, clinic symptom of the patients with chronic obstructive pulmonary disease can clearly improved, pulmonary function is increased, life quality is improved, and inflammation level and oxidative stress status are improved. The medicinal preparation has the characteristics of simple process, good reappearance, strong operationality, high yield, can greatly keep the active ingredients, and is especially suitable for industrial production. The preparation has the advantages of stable and controllable quality, excellent curative effect, low cost, and convenient storage and usage.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation for treating chronic obstructive pulmonary disease and a preparation method thereof. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a common and frequently-occurring disease that seriously endangers human health, seriously affects the quality of life of patients, and has a high mortality rate. heavy financial burden. According to the survey, it is estimated that by 2020, this disease will be the third cause of death in the world and the fifth in the world's economic burden of disease; at present, the prevalence of COPD among people over 40 years old in my country is as high as 8.2%. [0003] Regarding the treatment plan for COPD in clinical practice, "Guidelines for the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease (2013 Revision)" recommends the use of bronchodil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P11/00G01N30/02A61K35/62
Inventor 刘力徐德生张炜黄吉庚徐光临陈麒
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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